• European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations 

      Miehlke, Stephan; Guagnozzi, Danila; Zabana, Yamile; Tontini, Gian E; Fiehn, Anne-Marie Kanstrup; Wildt, Signe; Bohr, Johan; Bonderup, Ole K.; Bouma, Gerd; D’Amato, Mauro; Engel, Peter Johan Heiberg; Fernandez-Banares, Fernando; Macaigne, Gilles; Hjortswang, Henrik; Hultgren-Hörnquist, Elisabeth; Koulaouzidis, Anastasios; Kupcinskas, Jouzas; Landolfi, Stefania; Latella, Giovanni; Lucendo, Alfredo; Lyutakov, Ivan; Madisch, Ahmed; Magro, Fernando; Marlicz, Wojciech; Mihaly, Emese; Munck, Lars Kristian; Østvik, Ann Elisabet; Patai, Árpád V; Penchev, Plamen; Skonieczna-Żydecka, Karolina; Verhaegh, Bas; Münch, Andreas (Peer reviewed; Journal article, 2020)
      Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, ...
    • Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease 

      Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)
      Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ...
    • Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels 

      Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)
      Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...
    • The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis 

      Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan (Peer reviewed; Journal article, 2020)
      Background and Aims: Diarrhoea is a common, debilitating symptom of gastrointestinal disorders. Pathomechanisms probably involve defects in trans-epithelial water transport, but the role of aquaporin [AQP] family water ...