• European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations 

      Miehlke, Stephan; Guagnozzi, Danila; Zabana, Yamile; Tontini, Gian E; Fiehn, Anne-Marie Kanstrup; Wildt, Signe; Bohr, Johan; Bonderup, Ole K.; Bouma, Gerd; D’Amato, Mauro; Engel, Peter Johan Heiberg; Fernandez-Banares, Fernando; Macaigne, Gilles; Hjortswang, Henrik; Hultgren-Hörnquist, Elisabeth; Koulaouzidis, Anastasios; Kupcinskas, Jouzas; Landolfi, Stefania; Latella, Giovanni; Lucendo, Alfredo; Lyutakov, Ivan; Madisch, Ahmed; Magro, Fernando; Marlicz, Wojciech; Mihaly, Emese; Munck, Lars Kristian; Østvik, Ann Elisabet; Patai, Árpád V; Penchev, Plamen; Skonieczna-Żydecka, Karolina; Verhaegh, Bas; Münch, Andreas (Peer reviewed; Journal article, 2020)
      Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, ...
    • Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis 

      Bruland, Torunn; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)
      Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ...
    • Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease 

      Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)
      Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ...
    • Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis 

      Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)
      Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ...
    • Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease 

      Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)
      In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ...
    • Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium 

      Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)
      Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ...
    • Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease 

      Escudero-hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Munch, Andreas (Peer reviewed; Journal article, 2021)
      Background and aims: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, ...
    • Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels 

      Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)
      Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...
    • The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis 

      Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan (Peer reviewed; Journal article, 2020)
      Background and Aims: Diarrhoea is a common, debilitating symptom of gastrointestinal disorders. Pathomechanisms probably involve defects in trans-epithelial water transport, but the role of aquaporin [AQP] family water ...