• Assessing awareness of hypoglycemia in children and adolescents with type 1 diabetes: Evaluation of established questionnaires 

      Hatle, Håvard; Bjørgaas, Marit Ragnhild Rokne; Skrivarhaug, Torild; Åsvold, Bjørn Olav; Graveling, Alex; Frier, Brian; Rø, Torstein Baade (Journal article; Peer reviewed, 2019)
      Objective To evaluate the use of two questionnaires assessing awareness of hypoglycemia, in a pediatric type 1 diabetes (T1D) population. Methods Prospective observational study with children (aged 9‐18 years) and parents ...
    • Association of Conventional Cardiovascular Risk Factors With Cardiovascular Disease After Hypertensive Disorders of Pregnancy: Analysis of the Nord-Trøndelag Health Study 

      Haug, Eirin Beate; Horn, Julie; Markovitz, Amanda R; Fraser, Abigail; Klykken, Bjørnar E.; Dalen, Håvard; Vatten, Lars Johan; Romundstad, Pål Richard; Rich-Edwards, Janet W.; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2019)
      Importance Women with a history of hypertensive disorders of pregnancy (HDP) have higher risk of cardiovascular disease (CVD). It is not known how much of the excess CVD risk in women with a history of HDP is associated ...
    • Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses 

      Brumpton, Ben Michael; Sanderson, Eleanor; Heilbron, Karl; Hartwig, FP; Harrison, S; Vie, Gunnhild Åberge; Cho, Y; Howe, LD; Hughes, A; Boomsma, D; Havdahl, Alexandra; Hopper, J; Neale, M; Nivard, Michel G.; Pedersen, N; Reynolds, CA; Tucker-D, EM; Grotzinger, A; Howe, Laurence; Morris, Tim; Li, Shuai; Within-Family Consortium, The; 23andMe Research Team, The; Auton, A; Windmeijer, F; Chen, W-M; Bjørngaard, Johan Håkon; Hveem, Kristian; Willer, C; Evans, DM; Kaprio, J; Davey Smith, G; Åsvold, BO; Åsvold, Bjørn Olav; Hemani, G; Davies, Neil Martin (Peer reviewed; Journal article, 2020)
      Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ...
    • Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway 

      Jølle, Anne; Åsvold, Bjørn Olav; Holmen, Jostein; Carlsen, Sven Magnus; Tuomilehto, Jaakko; Bjørngaard, Johan Håkon; Midthjell, Kristian (Journal article; Peer reviewed, 2018)
      Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among ...
    • Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study 

      Rogne, Tormod; Solligård, Erik; Burgess, Stephen; Brumpton, Ben Michael; Paulsen, Julie; Pescott, Hallie; Mohus, Randi Marie; Gustad, Lise Tuset; Mehl, Arne; Åsvold, Bjørn Olav; DeWan, Andrew; Damås, Jan Kristian (Journal article; Peer reviewed, 2020)
    • Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals 

      Stanzick, Kira J.; Li, Yong; Schlosser, Pascal; Gorski, Mathias; Wuttke, Matthias; Thomas, Laurent F.; Rasheed, Humaira; Rowan, Bryce X.; Graham, Sarah E.; Vanderweff, Brett R.; Patil, Snehal B.; Robinson-Cohen, Cassiane; Gaziano, John M.; O’Donnell, Christopher J.; Willer, Cristen J.; Hallan, Stein; Åsvold, Bjørn Olav; Gessner, Andre; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna; Stark, Klaus; Heid, Iris M.; Winkler, Thomas W. (Journal article; Peer reviewed, 2021)
      Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ...
    • Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2019)
      Objective Low back pain (LBP) is a major problem in modern society and it is important to study possible risk factors for this disorder. People with diabetes are often affected by LBP, but whether diabetes represents a ...
    • The effect of smoking intensity on all-cause and cause-specific mortality-a Mendelian randomization analysis. 

      Vie, Gunnhild Åberge; Wootton, Robyn E; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Taylor, AE; Gabrielsen, Maiken Elvestad; Davey, George Smith; Romundstad, Pål Richard; Munafo, Marcus R (Peer reviewed; Journal article, 2019)
      Background Smoking is an important cause of mortality and recent studies have suggested that even low-intensity smoking might be associated with increased mortality. Still, smoking is associated with lower socio-economic ...
    • Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway 

      Mohus, Randi Marie; Gustad, Lise Tuset; Furberg, Anne-Sofie; Moen, Martine Kjølberg; Liyanarachi, Kristin Vardheim; Askim, Åsa Susanne; Åsberg, Signe Elisabeth; DeWan, Andrew T.; Rogne, Tormod; Simonsen, Gunnar Skov; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Peer reviewed; Journal article, 2022)
      Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ...
    • Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study) 

      Brandkvist, Maria Charlotta; Bjørngaard, Johan Håkon; Ødegård, Rønnaug; Brumpton, Ben Michael; Smith, George Davey; Åsvold, Bjørn Olav; Sund, Erik; Kvaløy, Kirsti; Willer, Cristen J.; Vie, Gunnhild Åberge (Peer reviewed; Journal article, 2020)
      Background Obesity has tripled worldwide since 1975 as environments are becoming more obesogenic. Our study investigates how changes in population weight and obesity over time are associated with genetic predisposition ...
    • Genome-wide association study of cardiac troponin i in the general population 

      Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E; Wolford, Brooke N; Hansen, Ailin Falkmo; Gagliano Taliun, Sarah A; Lefaive, Jonathon; Rasheed, Humaira; Thomas, Laurent; Zhou, Wei; Aung, Nay; Surakka, Ida; Douville, Nicholas J; Campbell, Archie; Porteous, David J; Petersen, Steffen E; Munroe, Patricia B; Welsh, Paul; Sattar, Naveed; Smith, George Davey; Fritsche, Lars G; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Hveem, Kristian; Hayward, Caroline; Willer, Cristen J; Brumpton, Ben M; Omland, Torbjørn (Peer reviewed; Journal article, 2021)
      Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) ...
    • GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 

      Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne R.; Karjalainen, Juha; Kurki, Mitja I.; Oneka, Morgan; Taylor, Peter; Fritsche, Lars; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Bordal, Eirin Haug; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana; Mayordomo, Jose; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark J.; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ...
    • An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms 

      Wildisen, Lea; Del Giovane, Cinzia; Moutzouri, Elisavet; Beglinger, Shanthi; Syrogiannouli, Lamprini; Collet, Tinh-Hai; Cappola, Anne R.; Åsvold, Bjørn Olav; Bakker, Stephan J.L.; Yeap, Bu B.; Almeida, Osvaldo P.; Ceresini, Graziano; Dullaart, Robin P. F.; Ferrucci, Luigi; Grabe, Hans J.; Jukema, J. Wouter; Nauck, Matthias; Trompet, Stella; Völzke, Henry; Westendorp, Rudi G.J.; Gussekloo, Jacobijn; Klöppel, Stefan; Aujesky, Drahomir; Bauer, Douglas C.; Peeters, Robin P.; Feller, Martin; Rodondi, Nicolas (Peer reviewed; Journal article, 2020)
      In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and ...
    • Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes 

      Hjort, Rebecka; Löfvenborg, Josefin E.; Ahlqvist, Emma; Alfredsson, Lars; Andersson, Tomas; Grill, Valdemar Erik Robert; Groop, Leif; Sørgjerd, Elin Pettersen; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2019)
      Objective We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in ...
    • Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health 

      Wang, Geng; Bhatta, Laxmi; Moen, Gunn-Helen; Hwang, Liang-Dar; Kemp, John P.; Bond, Tom A.; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M.; Warrington, Nicole M. (Peer reviewed; Journal article, 2021)
      Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether ...
    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...
    • Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease 

      Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars; Gagliano Taliun, Sarah; Sidore, Carlo; Liu, Yuhao; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke; Overton, William; Zhao, Ying; Chen, Jin; Zhang, He; Hornsby, Whitney E.; Acheampong, Akua; Grooms, Austen; Schaefer, Amanda; Zajac, Gregory J.M.; Villacorta, Luis; Zhang, Jifeng; Brumpton, Ben Michael; Løset, Mari; Rai, Vivek; Lundegaard, Pia R.; Olesen, Morten S.; Taylor, Kent D.; Palmer, Nicholette D.; Chen, Yii-Der; Choi, Seung Hoan; Lubitz, Steven A.; Ellinor, Patrick T.; Barnes, Kathleen C.; Daya, Michelle; Rafaels, Nicholas; Weiss, Scott T.; Lasky-Su, Jessica; Tracy, Russell P.; Vasan, Ramachandran S.; Cupples, L. Adrienne; Mathias, Rasika A.; Yanek, Lisa R.; Becker, Lewis; Holmen, Oddgeir Lingaas; Åsvold, Bjørn Olav; Willer, Christen; Hveem, Kristian (Peer reviewed; Journal article, 2020)
      Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse ...
    • Low thyroid function is not associated with an accelerated deterioration in renal function 

      Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn Olav; Bjøro, Trine; Vatten, Lars Johan; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M.; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J. (Peer reviewed; Journal article, 2019)
      Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the ...
    • Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort 

      Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.; Kirkpatrick, Robert M.; Warrington, Nicole Maree; Evans, David M. (Peer reviewed; Journal article, 2020)
      There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse ...
    • MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk 

      Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke N.; Graham, Sarah E.; Chen, Y. Eugene; Lee, Seunggeun; Kang, Hyun Min; Langhammer, Arnulf; Forsmo, Siri; Åsvold, Bjørn Olav; Styrkarsdottir, Unnur; Holm, Hilma; Gudbjartsson, Daniel F.; Stefansson, Kari; Baras, Aris; Bai, Xiaodong; Balasubramanian, Suganthi; Barnard, Leland; Blumenfeld, Andrew; Cantor, Michael; Coppola, Giovanni; Economides, Aris; Eom, Gisu; Habegger, Lukas; Hahn, Young; Hawes, Alicia; Jones, Marcus B.; Khalid, Shareef; Lotta, Luca A.; Maxwell, Evan K.; Mitnaul, Lyndon J.; Overton, John D.; Reid, Jeffrey G.; Ferreira, Manuel Allen Revez; Salerno, William; Sharma, Deepika; Shuldiner, Alan R.; Staples, Jeffrey C.; Yadav, Ashish; Abecasis, Goncalo R.; Hveem, Kristian; Willer, Cristen J. (Peer reviewed; Journal article, 2020)
      A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ...