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    • Systematic review: predictive value of organoids in colorectal cancer 

      Sakshaug, Baard Cristoffer; Folkesson, Emma Evelina; Haukaas, Tonje Husby; Visnes, Torkild; Flobak, Åsmund (Peer reviewed; Journal article, 2023)
      While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools to match ...

    • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 

      Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Peer reviewed; Journal article, 2022)
      Background Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...

    • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study 

      Rath, Eivind; Palma Medina, Laura M.; Jahagirdar, Sanjeevan; Mosevoll, Knut Anders; Damås, Jan Kristian; Madsen, Martin B.; Svensson, Mattias; Hyldegaard, Ole; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Norrby-Teglund, Anna; Skrede, Steinar; Bruun, Trond (Peer reviewed; Journal article, 2023)
      Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ...

    • Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study 

      Chaban, Viktoriia; Clarke, Gerard; Skandsen, Toril; Islam, Rakibul; Einarsen, Cathrine Elisabeth; Vik, Anne; Damås, Jan Kristian; Mollnes, Tom Eirik; Håberg, Asta; Pischke, Soeren (Peer reviewed; Journal article, 2020)
      Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate immune activation are unknown. We determined ...

    • Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation 

      Holm, Mari; Morken, Tora Sund; Fichorova, Raina Nakove; VanderVeen, Deborah; Allred, Elizabeth; Dammann, Olaf; Leviton, Alan (Peer reviewed; Journal article, 2017)
      PURPOSE. To assess the association between systemic levels of inflammation-associated proteins and severe retinopathy of prematurity (ROP) in extremely preterm infants. METHODS. We collected whole blood on filter paper on ...

    • Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention 

      Rø, Anne Dorthea Bjerkenes; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae (Peer reviewed; Journal article, 2023)
      Background Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim ...

    • Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing 

      Delaleu, Nicolas; Marti, Hans Peter; Strauss, Philipp; Sekulic, Miroslav; Osman, Tarig Al-Hadi; Tøndel, Camilla; Skrunes, Rannveig; Leh, Sabine; Svarstad, Einar; Nowak, Albina; Gaspert, Ariana; Rusu, Elena; Kwee, Ivo; Rinaldi, Andrea; Flatberg, Arnar; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2023)
      Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ...

    • T1 bladder cancer in Norway: treatment and survival 

      Blindheim, Augun Jodis; Fosså, Sophie Dorothea; Babigumira, Ronnie; Myklebust, Tor Åge; Haug, Erik Skaaheim; Arum, Carl-Jørgen; Kulle, Bettina (Peer reviewed; Journal article, 2020)
      Aim: Evaluation of treatment and survival of pT1 stage (T1) bladder cancer (BC) patients diagnosed with transitional cell carcinoma of the urinary bladder in Norway. Material and methods: According to the Cancer Registry ...

    • Tailored surgery in chronic pancreatitis after implementation of a multidisciplinary team assessment; a prospective observational study 

      Waage, Anne; Holmquist, Olof Dan Sebastian; Labori, Knut Jørgen; Paulsen, Vemund; Aabakken, Lars; Lenz, Harald; Felix Magnus, Henrik C.; Tholfsen, Tore; Hauge, Truls (Peer reviewed; Journal article, 2022)
      Introduction - Optimal management of chronic pancreatitis involves several specialties. Selection of patients for surgery may benefit from evaluation by a multidisciplinary team (MDT), similar to cancer care. The aim of ...

    • Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury 

      Wilson, Lindsay; Horton, Lindsay; Polinder, Suzanne; Newcombe, Virginia F.J.; Steinbuechel, Nicole v.; Maas, Andrew I. R.; Menon, David K; Åkerlund, Cecilia; Andelic, Nada; Andreassen, Lasse; Vik, Anne; Anke, Audny Gabriele Wagner; Skandsen, Toril; Frisvold, Shirin; Røise, Olav; Helseth, Eirik; DAHL, HILDE MARGRETE; Røe, Cecilie; Audibert, Gérard; Azouvi, Philippe; Azzolini, Maria Luisa; Barzó, Pál; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emaliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Cavallo, Simona; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Clusmann, Hans; Coburn, Mark; Coles, Jonathan (Peer reviewed; Journal article, 2022)
      There is increasing emphasis on assessing multi-dimensional outcomes in traumatic brain injury (TBI), but achieving this aim is hampered by a plethora of overlapping assessment tools. There is a clear need for advice on ...

    • TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma 

      Håland, Erling; Moen, Ingrid Nyhus; Vandsemb, Esten Nymoen; Starheim, Kristian K. (Peer reviewed; Journal article, 2022)
      Objective Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the ...

    • Take-home naloxone for the emergency interim management of opioid overdose: The public health application of an emergency medicine 

      Strang, John; McDonald, Rebecca; Campbell, Gabrielle; Degenhardt, Louisa; Nielsen, Suzanne; Ritter, Alison; Dale, Ola (Peer reviewed; Journal article, 2019)
      Naloxone is a well-established essential medicine for the treatment of life-threatening heroin/opioid overdose in emergency medicine. Over two decades, the concept of ‘take-home naloxone’ has evolved, comprising pre-provision ...

    • Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study 

      Howe, Laurence J.; Brumpton, Ben Michael; Rasheed, Humaira; Åsvold, Bjørn Olav; Davey Smith, George; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Background: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships ...

    • Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer 

      Singh, Ashish Kumar; McPhillips, Mary; Talseth-Palmer, Bente; Lavik, Liss Ane; Xavier, Alexandre; Drabløs, Finn; Sjursen, Wenche (Peer reviewed; Journal article, 2020)
      Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification ...

    • Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts 

      Krüger, Tormod Bjartveit; Syversen, Unni; Herlofson, Bente Brokstad; Lian, Aina-Mari; Reseland, Janne Elin (Peer reviewed; Journal article, 2022)
      Objective Bisphosphonates like alendronate mainly exert their effects on osteoclasts. However, osteoblasts are also affected, but exposed to a much lower concentration in vivo than the osteoclasts. Given that the effects ...

    • Targeting Internalizing Symptoms in Children: What is the Impact on School Functioning? 

      Pedersen, Marit Løtveit; Holen, Solveig; Sund, Anne Mari; Adolfsen, Frode; Løvaas, Mona Elisabeth S; Martinsen, Kristin; Neumer, Simon-Peter; Patras, Joshua; Rasmussen, Lene-Mari Potulski; Lydersen, Stian (Peer reviewed; Journal article, 2022)
      Internalizing problems may be associated with poor academic performance and school absenteeism among youth. This study investigated the impact of the EMOTION: “Coping Kids” Managing Anxiety and Depression Program on academic ...

    • Targeting Internalizing Symptoms in Children: What is the Impact on School Functioning? 

      Pedersen, Marit Løtveit; Holen, Solveig; Sund, Anne Mari; Adolfsen, Frode; Løvaas, Mona Elisabeth S; Martinsen, Kristin; Neumer, Simon-Peter; Patras, Joshua; Rasmussen, Lene-Mari Potulski; Lydersen, Stian (Peer reviewed; Journal article, 2022)
      Internalizing problems may be associated with poor academic performance and school absenteeism among youth. This study investigated the impact of the EMOTION: “Coping Kids” Managing Anxiety and Depression Program on academic ...

    • Targeting phosphoglycerate dehydrogenase in multiple myeloma 

      Elsaadi, Samah; Steiro, Ida Johnsen; Abdollahi, Pegah; Vandsemb, Esten; Yang, Rui; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Menu, Eline; Sponaas, Anne-Marit; Børset, Magne (Peer reviewed; Journal article, 2021)
      Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. ...

    • Team approach: Multidisciplinary treatment of hip fractures in elderly patients: Orthogeriatric care 

      Figved, Wender; Myrstad, Marius; Saltvedt, Ingvild; Finjarn, Merete; Odland, Liv Marie Flaten; Frihagen, Frede Jon (Journal article; Peer reviewed, 2019)
      Patients with hip fractures are best managed by a multidisciplinary team. The multidisciplinary team consists of an orthogeriatrician, orthopaedic surgeon, aanesthesiologist, orthopaedic and/or geriatric nurse, occupational ...

    • Technologies for assessment of bone reflecting bone strength and bone mineral density in elderly women: An update 

      Dhainaut, Alvilde; Hoff, Mari; Syversen, Unni; Haugeberg, Glenn (Peer reviewed; Journal article, 2016)
      Reduced bone mineral density is a strong risk factor for fracture. The WHO’s definition of osteoporosis is based on bone mineral density measurements assessed by dual x-ray absorptiometry. Several on other techniques than ...