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Quantifying Valve Regurgitation using 3-D Doppler Ultrasound Images and Deep Learning
(Peer reviewed; Journal article, 2022)Accurate quantification of cardiac valve regurgitation jets is fundamental for guiding treatment. Cardiac ultrasound is the preferred diagnostic tool, but current methods for measuring the regurgitant volume (RVol) are ... -
Quantifying Valve Regurgitation Using 3-D Doppler Ultrasound Images and Deep Learning
(Peer reviewed; Journal article, 2022)Accurate quantification of cardiac valve regurgitation jets is fundamental for guiding treatment. Cardiac ultrasound is the preferred diagnostic tool, but current methods for measuring the regurgitant volume are limited ... -
Quantitation of linear and branched perfluoroalkane sulfonic acids (PFSAs) in women and infants during pregnancy and lactation
(Peer reviewed; Journal article, 2021)Background - Per- and polyfluoroalkyl substances (PFAS) are associated with negative health effects, and exposure during fetal life and infancy are of concern. A subgroup of PFAS, linear and branched perfluoroalkane sulfonic ... -
Quantitative and clinical impact of MRI-based attenuation correction methods in[18F]FDG evaluation of dementia
(Journal article; Peer reviewed, 2019)Background Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examination ... -
Quantitative comparison of PET performance-Siemens Biograph mCT and mMR
(Peer reviewed; Journal article, 2016)Background: Integrated clinical whole-body PET/MR systems were introduced in2010. In order to bring this technology into clinical usage, it is of great importance to compare the performance with the well-established PET/CT. ... -
A questionnaire of knowledge, attitude and practices on tuberculosis among medical interns in Nepal
(Peer reviewed; Journal article, 2020)Background Tuberculosis (TB) remains a major health problem worldwide, including in Nepal where around 33,000 new cases of TB were diagnosed in 2018 and 5400 patients died. There are challenges in the diagnostic process, ... -
Questionnaires vs Interviews for the Assessment of Global Functional Outcomes After Traumatic Brain Injury
(Peer reviewed; Journal article, 2021)Importance An interview is considered the gold standard method of assessing global functional outcomes in clinical trials among patients with acute traumatic brain injury (TBI). However, several multicenter clinical trials ... -
R1352Q CACNA1A variant in a patient with sporadic hemiplegic migrainem ataxia, seizures and cerebral oedema: A case report
(Journal article; Peer reviewed, 2021)Mutations in the CACNA1A gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head ... -
Radiological assessment of chest compression point and achievable compression depth in cardiac patients
(Peer reviewed; Journal article, 2016)Background Using magnetic resonance imaging (MRI) to relate cardiovascular structures to surface anatomy in a population relevant to cardiac arrest victims, relate the external thoracic anterior-posterior (AP) diameter ... -
Radiotherapy for prostate cancer – Does daily image guidance with tighter margins improve patient reported outcomes compared to weekly orthogonal verified irradiation? Results from a randomized controlled trial
(Journal article; Peer reviewed, 2018)Background Novel cancer drugs are subject to strict scientific evaluation of safety and efficacy and usually undergo a cost effectiveness analysis before approval for use in clinical practice. For new techniques in ... -
Raidionics: an open software for pre- and postoperative central nervous system tumor segmentation and standardized reporting
(Peer reviewed; Journal article, 2023)For patients suffering from central nervous system tumors, prognosis estimation, treatment decisions, and postoperative assessments are made from the analysis of a set of magnetic resonance (MR) scans. Currently, the lack ... -
Randomised controlled trial of preconception lifestyle intervention on maternal and offspring health in people with increased risk of gestational diabetes: study protocol for the BEFORE THE BEGINNING trial
(Peer reviewed; Journal article, 2023)Introduction: Gestational diabetes mellitus (GDM) is associated with increased risk for type 2 diabetes in the mother and cardiometabolic diseases in the child. The preconception period is an optimal window to adapt the ... -
Randomised, placebo-controlled, double-blinded trial of fecal microbiota transplantation in severe obesity: a study protocol
(Peer reviewed; Journal article, 2023)Introduction - Obesity is one of the main threats to public health in western countries and increases the risk of several diseases, overall morbidity and mortality. Sustained weight loss will reduce risk factors and improve ... -
Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway
(Peer reviewed; Journal article, 2022)Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening ... -
Randomized phase III trial comparing switch-maintenance pemetrexed with observation followed by pemetrexed at progression in advanced NSCLC
(Peer reviewed; Journal article, 2020)Objectives: Two phase III trials show that maintenance pemetrexed therapy after platinum-doublet chemotherapy prolongs overall survival (OS) and progression free survival (PFS) in advanced non-squamous non-small-cell lung ... -
A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients
(Peer reviewed; Journal article, 2015)Background:The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibilityand on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less ... -
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
(Journal article; Peer reviewed, 2021)Background - Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as ... -
Rapid destructive osteoarthritis of the hip: Vanishing femoral head with MRI findings mimicking septic arthritis
(Journal article, 2019)Introduction: Rapid destructive osteoarthritis of the hip is a rare disorder of unknown etiology characterized by rapid destruction of the hip joint. We present a case with complete destruction of the femoral head and ... -
Rates of subjective and objective cure, satisfaction, and pain 10–20 years after tension-free vaginal tape (TVT) surgery: A retrospective cohort study
(Peer reviewed; Journal article, 2023)Objective To evaluate rates of subjective and objective cure, treatment satisfaction, pain, and the correlation between cure and body mass index (BMI), at 10 and 20 years after tension-free vaginal tape (TVT) surgery. ... -
Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial
(Journal article, 2021)Background Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt ...