dc.contributor.author | Ursin, Kristin | |
dc.contributor.author | Lydersen, Stian | |
dc.contributor.author | Skomsvoll, Johan Fredrik | |
dc.contributor.author | Wallenius, Marianne | |
dc.date.accessioned | 2019-05-06T09:10:19Z | |
dc.date.available | 2019-05-06T09:10:19Z | |
dc.date.created | 2018-07-02T21:43:00Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Rheumatology. 2018, 57 (6), 1064-1071. | nb_NO |
dc.identifier.issn | 1462-0324 | |
dc.identifier.uri | http://hdl.handle.net/11250/2596558 | |
dc.description.abstract | Objective
The aim was to study disease activity in women with axial spondyloarthritis (axSpA) during and after pregnancy.
Methods
The study included 179 pregnancies in 166 women with axSpA from a Norwegian nationwide register. Disease activity was assessed at seven time points before, throughout and after pregnancy with the DAS BASDAI. Scores assessed at each time point were analysed in a linear mixed model. The same statistical method was used to study self-reported physical functioning, pain and mental health.
Results
Altogether, disease activity was stable throughout the study period. We found the highest disease activity and worst self-reported pain in the second trimester, when 45% of the women had active disease. At this time point, disease activity was significantly higher than 6 weeks postpartum (mean BASDAI 3.97 vs 3.46, P = 0.005). Self-reported mental health was also stable, but significantly better 6 weeks postpartum than in the first trimester (mean RAND-36 mental health 79.3 vs 73.2, P < 0.001). Physical functioning was significantly worse in third trimester than postpartum (mean BASFI 3.6 vs 2.6, P < 0.001).
Conclusion
Studying women with axSpA, we found that disease activity was highest in the second trimester, but altogether low and stable in the period from planning pregnancy to 1 year after delivery. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.title | Disease activity during and after pregnancy in women with axial spondyloarthritis: a prospective multicentre study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 1064-1071 | nb_NO |
dc.source.volume | 57 | nb_NO |
dc.source.journal | Rheumatology | nb_NO |
dc.source.issue | 6 | nb_NO |
dc.identifier.doi | 10.1093/rheumatology/key047 | |
dc.identifier.cristin | 1595306 | |
dc.description.localcode | This is a pre-copyedited, author-produced version of an article accepted for publication in [Rheumatology] following peer review. The version of record is available online at: https://doi.org/10.1093/rheumatology/key047 | nb_NO |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 194,65,35,5 | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | RKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |