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dc.contributor.authorUrsin, Kristin
dc.contributor.authorLydersen, Stian
dc.contributor.authorSkomsvoll, Johan Fredrik
dc.contributor.authorWallenius, Marianne
dc.date.accessioned2019-05-06T09:10:19Z
dc.date.available2019-05-06T09:10:19Z
dc.date.created2018-07-02T21:43:00Z
dc.date.issued2018
dc.identifier.citationRheumatology. 2018, 57 (6), 1064-1071.nb_NO
dc.identifier.issn1462-0324
dc.identifier.urihttp://hdl.handle.net/11250/2596558
dc.description.abstractObjective The aim was to study disease activity in women with axial spondyloarthritis (axSpA) during and after pregnancy. Methods The study included 179 pregnancies in 166 women with axSpA from a Norwegian nationwide register. Disease activity was assessed at seven time points before, throughout and after pregnancy with the DAS BASDAI. Scores assessed at each time point were analysed in a linear mixed model. The same statistical method was used to study self-reported physical functioning, pain and mental health. Results Altogether, disease activity was stable throughout the study period. We found the highest disease activity and worst self-reported pain in the second trimester, when 45% of the women had active disease. At this time point, disease activity was significantly higher than 6 weeks postpartum (mean BASDAI 3.97 vs 3.46, P = 0.005). Self-reported mental health was also stable, but significantly better 6 weeks postpartum than in the first trimester (mean RAND-36 mental health 79.3 vs 73.2, P < 0.001). Physical functioning was significantly worse in third trimester than postpartum (mean BASFI 3.6 vs 2.6, P < 0.001). Conclusion Studying women with axSpA, we found that disease activity was highest in the second trimester, but altogether low and stable in the period from planning pregnancy to 1 year after delivery.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Pressnb_NO
dc.titleDisease activity during and after pregnancy in women with axial spondyloarthritis: a prospective multicentre studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1064-1071nb_NO
dc.source.volume57nb_NO
dc.source.journalRheumatologynb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.1093/rheumatology/key047
dc.identifier.cristin1595306
dc.description.localcodeThis is a pre-copyedited, author-produced version of an article accepted for publication in [Rheumatology] following peer review. The version of record is available online at: https://doi.org/10.1093/rheumatology/key047nb_NO
cristin.unitcode194,65,30,0
cristin.unitcode194,65,35,5
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameRKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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