Blar i Publikasjoner fra Cristin - St. Olavs hospital på tidsskrift "Nature Communications"
Viser treff 1-5 av 5
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Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
(Peer reviewed; Journal article, 2020)Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ... -
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
(Peer reviewed; Journal article, 2021)Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first ... -
Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development
(Peer reviewed; Journal article, 2024)Heart failure (HF) causes substantial morbidity and mortality but its pathobiology is incompletely understood. The proteome is a promising intermediate phenotype for discovery of novel mechanisms. We measured 4877 plasma ... -
MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk
(Peer reviewed; Journal article, 2020)A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ... -
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
(Journal article; Peer reviewed, 2024)Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates ...