Browsing Publikasjoner fra Cristin - St. Olavs hospital by Journals "European Journal of Clinical Pharmacology"

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Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study

Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Peer reviewed; Journal article, 2020)

Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...