Blar i Publikasjoner fra Cristin - St. Olavs hospital på forfatter "Bathen, Tone Frost"
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2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping
Esmaeili, Morteza; Vettukattil, Riyas M; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). ... -
Accuracy of breast cancer lesion classification using intravoxel incoherent motion diffusion-weighted imaging is improved by the inclusion of global or local prior knowledge with bayesian methods
Vidic, Igor; Jerome, Neil Peter; Bathen, Tone Frost; Goa, Pål Erik; While, Peter Thomas (Journal article; Peer reviewed, 2019)Background Diffusion‐weighted MRI (DWI) has potential to noninvasively characterize breast cancer lesions; models such as intravoxel incoherent motion (IVIM) provide pseudodiffusion parameters that reflect tissue perfusion, ... -
Assessing treatment response and prognosis by serum and tissue metabolomics in breast cancer patients
Debik, Julia Barbara; Euceda, Leslie R.; Lundgren, Steinar; Gythfeldt, Hedda; Garred, Øystein; Borgen, Elin; Engebråten, Olav; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)Patients with locally advanced breast cancer have a worse prognosis compared to patients with localized tumors and require neoadjuvant treatment before surgery. The aim of this study was to characterize the systemic metabolic ... -
Association of serum cortisol and cortisone levels and risk of recurrence after endocrine treatment in breast cancer
Wang, Feng; Giskeødegård, Guro F.; Skarra, Sissel; Engstrøm, Monica Jernberg; Hagen, Lars; Geisler, Jürgen; Mikkola, Tomi S.; Tikkanen, Matti J.; Debik, Julia; Reidunsdatter, Randi Johansen; Bathen, Tone Frost (Peer reviewed; Journal article, 2023)Metabolic reprogramming in breast cancer involves changes in steroid hormone synthesis and metabolism. Alterations in estrogen levels in both breast tissue and blood may influence carcinogenesis, breast cancer growth, and ... -
Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study
Nodeland, Markus; Klevjer, Marie; Sæther, Julie Caroline; Giskeødegård, Guro F.; Bathen, Tone Frost; Wisløff, Ulrik; Bye, Anja (Journal article; Peer reviewed, 2022) -
Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI
Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ... -
Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Andreassen, Maren Marie Sjaastad; Rodriguez-Soto, Ana; Conlin, CC; Vidić, I; Seibert, TM; Wallace, AM; Zare, S; Kuperman, J; Abudu, B; Ahn, GS; Hahn, M; Jerome, Neil Peter; Østlie, Agnes; Bathen, Tone Frost; Ojeda-Fournier, H; Goa, Pål Erik; Rakow-Penner, Rebecca; Dale, AM (Peer reviewed; Journal article, 2020)Purpose: Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from ... -
Evaluating the Impact of High Intensity Interval Training on Axial Psoriatic Arthritis Based on MR Images
Chronaiou, Ioanna; Giskeødegård, Guro F.; Neubert, Ales; Hoffmann-Skjøstad, Tamara Viola; Thomsen, Ruth Stoklund; Hoff, Mari; Bathen, Tone Frost; Sitter, Beathe (Journal article; Peer reviewed, 2022)High intensity interval training (HIIT) has been shown to benefit patients with psoriatic arthritis (PsA). However, magnetic resonance (MR) imaging has uncovered bone marrow edema (BME) in healthy volunteers after vigorous ... -
Feasibility of contrast-enhanced MRI derived textural features to predict overall survival in locally advanced breast cancer.
Chronaiou, Ioanna; Giskeødegård, Guro F.; Goa, Pål Erik; Teruel, Jose; Hedayati, Roja; Lundgren, Steinar; Huuse, Else Marie; Pickles, Martin D.; Gibbs, Peter; Sitter, Beathe; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)Background The prognosis for women with locally advanced breast cancer (LABC) is poor and there is a need for better treatment stratification. Gray-level co-occurrence matrix (GLCM) texture analysis of magnetic resonance ... -
Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer
Rye, Morten Beck; Bertilsson, Helena; Drabløs, Finn; Angelsen, Anders; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2014)Background Good prognostic tools for predicting disease progression in early stage prostate cancer (PCa) are still missing. Detection of molecular subtypes, for instance by using microarray gene technology, can give new ... -
The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems
Rye, Morten Beck; Krossa, Sebastian; Hall, Martina; van Mourik, Casper; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt; Bertilsson, Helena (Peer reviewed; Journal article, 2022)High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological ... -
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study
Sperstad, Sigri Bakken; Sæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Røsbjørgen, Ragnhild; Dalen, Håvard; Bye, Anja (Peer reviewed; Journal article, 2023)Background Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI. Aim We ... -
Metabolic characterization of triple negative breast cancer
Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies
Krüger-Stokke, Brage; Bertilsson, Helena; Langørgen, Sverre; Sjøbakk, Torill Eidhammer; Bathen, Tone Frost; Selnæs, Kirsten Margrete (Peer reviewed; Journal article, 2021)Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ... -
Pelvic PET/MR attenuation correction in the image space using deep learning
Abrahamsen, Bendik Skarre; Knudtsen, Ingerid Søberg Skjei; Eikenes, Live; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2023) -
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy
Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Peer reviewed; Journal article, 2023)Background The dual upregulation of TOP2A and EZH2 gene expression has been proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical prostatectomy. A low tissue level of the metabolite ... -
Pseudo-T2 mapping for normalization of T2-weighted prostate MRI
Sørland, Kaia Ingerdatter; Sunoqrot, Mohammed R. S.; Sandsmark, Elise; Langørgen, Sverre; Bertilsson, Helena; Trimble, Christopher George; Lin, Gigin; Selnæs, Kirsten Margrete; Goa, Pål Erik; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2022)Objective Signal intensity normalization is necessary to reduce heterogeneity in T2-weighted (T2W) magnetic resonance imaging (MRI) for quantitative analysis of multicenter data. AutoRef is an automated dual-reference ... -
A Quality Control System for Automated Prostate Segmentation on T2-Weighted MRI
Sunoqrot, Mohammed R. S.; Selnæs, Kirsten Margrete; Sandsmark, Elise; Nketiah, Gabriel Addio; Zavala-Romero, Olmo; Stoyanova, Radka; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2020)Computer-aided detection and diagnosis (CAD) systems have the potential to improve robustness and efficiency compared to traditional radiological reading of magnetic resonance imaging (MRI). Fully automated segmentation ... -
Reducing prostate biopsies and magnetic resonance imaging with prostate cancer risk stratification
Davik, Petter; Remmers, Sebastiaan; Elschot, Mattijs; Roobol, Monique J; Bathen, Tone Frost; Bertilsson, Helena (Journal article; Peer reviewed, 2022)