• Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial 

      Barratt-Due, Andreas; Olsen, Inge Christoffer; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Lund-Johansen, Fridtjof; Hoel, Hedda Benedicte; Holten, Aleksander Rygh; Tveita, Anders Aune; Mathiessen, Alexander; Haugli, Mette; Eiken, Ragnhild; Kildal, Anders Benjamin; Berg, Åse; Johannessen, Asgeir; Heggelund, Lars; Dahl, Tuva Børresdatter; Skåra, Karoline Hansen; Pawel, Mielnik; Le, Lan Ai Kieu; Thoresen, Lars; Ernst, Gernot; Hoff, Dag Arne Lihaug; Skudal, Hilde Kristin; Kittang, Bård Reiakvam; Olsen, Roy Bjørkholt; Tholin, Birgitte; Ystrøm, Carl Magnus; Skei, Nina Vibeche; Tran, Trung; Dudman, Susanne Gjeruldsen; Andersen, Jan Terje; Hannula, Raisa; Dalgard, Olav; Finbråten, Ane-Kristine; Tonby, Kristian; Blomberg, Bjørn; Aballi, Saad; Fladeby, Cathrine; Steffensen, Anne Katrine; Müller, Fredrik; Dyrhol-Riise, Anne Ma; Trøseid, Marius; Aukrust, Pål (Peer reviewed; Journal article, 2021)
      Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the ...
    • Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9 

      Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Dyrhol-Riise, Anne Ma; Stiksrud, Birgitte; Haugli, Mette; Blomberg, Bjørn; Kittang, Bård Reiakvam; Johannessen, Asgeir; Hannula, Raisa; Aballi, Saad; Kildal, Anders Benjamin; Eiken, Ragnhild; Dahl, Tuva Børresdatter; Lund-Johansen, Fridtjof; Müller, Fredrik; Rivero, Jezabel Rodriguez; Meltzer, Carin; Einvik, Gunnar; Ueland, Thor; Olsen, Inge Christoffer; Barratt-Due, Andreas; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning (Peer reviewed; Journal article, 2021)
      The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), ...
    • Platelet transfusions in adult ICU patients with thrombocytopenia: A sub-study of the PLOT-ICU inception cohort study 

      Anthon, Carl Thomas; Pène, Frédéric; Perner, Anders; Azoulay, Elie; Puxty, Kathryn; Van De Louw, Andry; Chawla, Sanjay; Castro, Pedro; Povoa, Pedro; Coelho, Luis; Metaxa, Victoria; Kochanek, Matthias; Liebregts, Tobias; Kander, Thomas; Sivula, Mirka; Andreasen, Jo Bønding; Nielsen, Lene Bjerregaard; Hvas, Christine Lodberg; Dufranc, Etienne; Canet, Emmanuel; Wright, Christopher John; Schmidt, Julien; Uhel, Fabrice; Missri, Louai; Krag, Mette; Cos Badia, Elisabet; Díaz-Lagares, Cándido; Menat, Sophie; Voiriot, Guillaume; Erikstrup Clausen, Niels; Lorentzen, Kristian; Kvåle, Reidar; Barratt-Due, Andreas; Hildebrandt, Thomas; Holten, Aleksander Rygh; Strand, Kristian; Bestle, Morten Heiberg; Klepstad, Pål; Vimpere, Damien; Paulino, Carolina; Lueck, Catherina; Juhl, Christian Svendsen; Costa, Carolina; Bådstøløkken, Per Martin; Lêdo, Lia Susana Aires; Møller, Morten Hylander; Russell, Lene (Peer reviewed; Journal article, 2024)
      Background Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown. Study design and methods Sub-study ...
    • Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses 

      Pan, Hongchao; Peto, Richard; Karim, Quarraisha Abdool; Alejandria, Marissa M.; Henao-Restrepo, Ana-Maria; Hernández-García, César; Kieny, Marie-Paule; Malekzadeh, Reza; Murthy, Srinivas; Preziosi, Marie-Pierre; Reddy, K Srinath; Periago, Mirta Roses; Sathiyamoorthy, Vasee; Røttingen, John-Arne; Swaminathan, Soumya; Ryan, Michael; Maggioni, Aldo; Babiker, Abdel; Cook, Deborah; Dondorp, Arjen; Kang, Gagandeep; Aukrust, Pål; Barratt-Due, Andreas; Dalgard, Olav; Vinge, Leif Erik; Kittang, Bård Reiakvam; Blomberg, Bjørn; Ystrøm, Carl Magnus; Eiken, Ragnhild; Skei, Nina Vibeche; Hoel, Hedda; Tholin, Birgitte; Hoff, Dag Arne Lihaug; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Kåsine, Trine; Nezvalova-Henriksen, Katerina; Olsen, Inge Christoffer; Trøseid, Marius; Aballi, Saad; Bjørkholt Olsen, Roy; Haugli, Mette; Berg, Åse; Skudal, Hilde Kristin; Hannula, Raisa; Kildal, Anders Benjamin; Johannessen, Asgeir; Tveita, Anders Aune; Heggelund, Lars; Ernst, Gernot Walter; Thoresen, Lars (Peer reviewed; Journal article, 2022)
      Background The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued ...
    • Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations 

      Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian; Barratt-Due, Andreas; Kåsine, Trine; Dyrhol-Riise, Anne Ma; Stiksrud, Birgitte; Tonby, Kristian; Hoel, Hedda; Olsen, Inge Christoffer; Henriksen, Katerina N.; Tveita, Anders Aune; Manotheepan, Ravinea; Haugli, Mette; Eiken, Ragnhild; Berg, Åse; Halvorsen, Bente; Lekva, Tove; Ranheim, Trine; Michelsen, Annika Elisabeth; Kildal, Anders Benjamin; Johannessen, Asgeir; Thoresen, Lars; Skudal, Hilde Kristin; Kittang, Bård Reiakvam; Olsen, Roy Bjørkholt; Ystrøm, Carl Magnus; Skei, Nina Vibeche; Hannula, Raisa; Aballi, Saad; Kvåle, Reidar; Skjønsberg, Ole Henning; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Peer reviewed; Journal article, 2022)
      Background - Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract is involved in the disease, with gut barrier dysfunction and gut ...