dc.contributor.author | Sletmoen, Marit | |
dc.contributor.author | Gerken, Thomas A. | |
dc.contributor.author | Stokke, Bjørn Torger | |
dc.contributor.author | Burchell, Joy | |
dc.contributor.author | Brewer, C. Fred | |
dc.date.accessioned | 2019-03-15T12:20:32Z | |
dc.date.available | 2019-03-15T12:20:32Z | |
dc.date.created | 2018-11-23T14:14:52Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Glycobiology. 2018, 28 (7), 437-442. | nb_NO |
dc.identifier.issn | 0959-6658 | |
dc.identifier.uri | http://hdl.handle.net/11250/2590250 | |
dc.description.abstract | The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate–carbohydrate interactions, CCIs) of Tn (Tn–Tn) and STn (STn–STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.title | Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 437-442 | nb_NO |
dc.source.volume | 28 | nb_NO |
dc.source.journal | Glycobiology | nb_NO |
dc.source.issue | 7 | nb_NO |
dc.identifier.doi | 10.1093/glycob/cwy032 | |
dc.identifier.cristin | 1634320 | |
dc.description.localcode | This is a pre-copyedited, author-produced version of an article accepted for publication in Glycobiology following peer review. The version of record is available online at: https://doi.org/10.1093/glycob/cwy032 | nb_NO |
cristin.unitcode | 194,66,15,0 | |
cristin.unitcode | 194,66,20,0 | |
cristin.unitname | Institutt for bioteknologi og matvitenskap | |
cristin.unitname | Institutt for fysikk | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |