dc.contributor.author | Skjaervold, Nils Kristian | |
dc.contributor.author | Knai, Kathrine | |
dc.contributor.author | Elvemo, Nicolas-Andreas L. | |
dc.date.accessioned | 2019-02-26T14:02:07Z | |
dc.date.available | 2019-02-26T14:02:07Z | |
dc.date.created | 2018-06-29T22:00:50Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | PLoS ONE. 2018, 13 (4), . | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2587576 | |
dc.description.abstract | It is well-known that blood glucose oscillates with a period of approximately 15 min (900 s) and exhibits an overall complex behaviour in intact organisms. This complexity is not thoroughly studied, and thus, we aimed to decipher the frequency bands entailed in blood glucose regulation. We explored high-resolution blood glucose time-series sampled using a novel continuous intravascular sensor in four pigs under general anaesthesia for almost 24 hours. In all time series, we found several interesting oscillatory components, especially in the 5000–10000 s, 500–1000 s, and 50–100 s regions (0.0002–0.0001 Hz, 0.002–0.001 Hz, and 0.02–0.01 Hz). The presence of these oscillations is not permanent, as they come and go. This is the first report of glucose oscillations in the 50–100 s range. The origin of these oscillations and their role in overall blood glucose regulation is unknown. Although the sample size is small, we believe this finding is important for our understanding of glucose regulation and perhaps for our understanding of general homeostatic regulation in intact organisms. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Some oscillatory phenomena of blood glucose regulation: An exploratory pilot study in pigs | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 13 | nb_NO |
dc.source.volume | 13 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0194826 | |
dc.identifier.cristin | 1594919 | |
dc.description.localcode | © 2018 Skjaervold et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |