dc.contributor.author | Zotcheva, Ekaterina | |
dc.contributor.author | Bergh, Sverre | |
dc.contributor.author | Selbæk, Geir | |
dc.contributor.author | Krokstad, Steinar | |
dc.contributor.author | Håberg, Asta | |
dc.contributor.author | Strand, Bjørn Heine | |
dc.contributor.author | Ernstsen, Linda | |
dc.date.accessioned | 2019-01-29T10:09:27Z | |
dc.date.available | 2019-01-29T10:09:27Z | |
dc.date.created | 2018-10-17T13:23:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Journal of Alzheimer's Disease. 2018, . | nb_NO |
dc.identifier.issn | 1387-2877 | |
dc.identifier.uri | http://hdl.handle.net/11250/2582775 | |
dc.description.abstract | Background:
Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk.
Objective:
We investigated independent and joint associations of midlife moderate-to-vigorous PA (MVPA) and distress with incident dementia.
Methods:
Our study comprised 28,916 participants aged 30–60 years from the Nord-Trøndelag Health Study (HUNT1, 1984–1986). Data on MVPA and distress from HUNT1 was linked to the Health and Memory Study in Nord-Trøndelag for dementia case identification. Participants were followed from 1995 until 2011. We used adjusted Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI).
Results:
In fully adjusted analyses, MVPA was associated with a reduced dementia risk (HR 0.81, 95% CI 0.62–1.06), compared to no MVPA. Distress was associated with an increased dementia risk (HR 1.30, 95% CI 0.99–1.70). Compared to distressed participants not taking part in MVPA, non-distressed no-MVPA participants had a reduced dementia risk (HR 0.72, 95% CI 0.54–0.96). The same applied to distressed MVPA participants (HR 0.50, 95% CI 0.22–1.14), and non-distressed MVPA participants (HR 0.63, 95% CI 0.44–0.90). Our results indicated an additive interaction between MVPA and distress on dementia risk.
Conclusion:
Our results suggest that midlife MVPA reduces risk of incident dementia among both distressed and non-distressed individuals. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | IOS Press | nb_NO |
dc.title | Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study | nb_NO |
dc.title.alternative | Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 9 | nb_NO |
dc.source.volume | 66 | nb_NO |
dc.source.journal | Journal of Alzheimer's Disease | nb_NO |
dc.source.issue | 2 | nb_NO |
dc.identifier.doi | 10.3233/JAD-180768 | |
dc.identifier.cristin | 1621069 | |
dc.description.localcode | © 2018. This is the authors' accepted and refereed manuscript to the article. The final authenticated version is available online at: http://dx.doi.org/10.3233/JAD-180768 | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitcode | 194,65,30,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |