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dc.contributor.authorEldholm, Rannveig Sakshaug
dc.contributor.authorPersson, Karin Ester Torun
dc.contributor.authorBarca, Maria Lage
dc.contributor.authorKnapskog, Anne Brita
dc.contributor.authorCavallin, Lena
dc.contributor.authorEngedal, Knut
dc.contributor.authorSkovlund, Eva
dc.contributor.authorSaltvedt, Ingvild
dc.contributor.authorSelbaek, Geir
dc.identifier.citationBMC Geriatrics. 2018, 18 (120), .nb_NO
dc.description.abstractBackground: Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this study was to examine the association between vascular disease and vascular risk factors and progression of AD. Methods: In a longitudinal observational study in three Norwegian memory clinics, 282 AD patients (mean age 73. 3 years, 54% female) were followed for mean 24 (16–37) months. Vascular risk factors and vascular diseases were registered at baseline, and the vascular burden was estimated by the Framingham Stroke Risk Profile (FSRP). Cerebral medical resonance images (MRIs) were assessed for white matter hyperintensities (WMH), lacunar and cortical infarcts. The associations between vascular comorbidity and progression of dementia as measured by annual change in Clinical Dementia Rating Sum of Boxes (CDR-SB) scores were analysed by multiple regression analyses, adjusted for age and sex. Results: Hypertension occurred in 83%, hypercholesterolemia in 53%, diabetes in 9%, 41% were overweight, and 10% were smokers. One third had a history of vascular disease; 16% had heart disease and 15% had experienced a cerebrovascular event. MRI showed lacunar infarcts in 16%, WMH with Fazekas score 2 in 26%, and Fazekas score 3 in 33%. Neither the vascular risk factors and diseases, the FSRP score, nor cerebrovascular disease was associated with disease progression in AD. Conclusions: Although vascular risk factors and vascular diseases were prevalent, no impact on the progression of AD after 2 years was shown.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectCerebrovaskulære sykdommernb_NO
dc.subjectCerebrovascular diseasesnb_NO
dc.titleAssociation between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinicsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.subject.nsiVDP::Geriatri: 778nb_NO
dc.subject.nsiVDP::Geriatrics: 778nb_NO
dc.source.journalBMC Geriatricsnb_NO
dc.relation.projectExtraStiftelsen: 2011-2-151nb_NO
dc.relation.projectSamarbeidsorganet mellom Helse Midt-Norge og NTNU: 47071301nb_NO
dc.description.localcode© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal