Vis enkel innførsel

dc.contributor.authorEldholm, Rannveig Sakshaug
dc.contributor.authorBarca, Maria Lage
dc.contributor.authorPersson, Karin
dc.contributor.authorKnapskog, Anne-Brita
dc.contributor.authorKersten, Hege
dc.contributor.authorEngedal, Knut
dc.contributor.authorSelbæk, Geir
dc.contributor.authorBrækhus, Anne
dc.contributor.authorSkovlund, Eva
dc.contributor.authorSaltvedt, Ingvild
dc.date.accessioned2018-05-08T06:39:00Z
dc.date.available2018-05-08T06:39:00Z
dc.date.created2018-01-02T14:12:15Z
dc.date.issued2017
dc.identifier.citationJournal of Alzheimer's Disease. 2017, 61 (3), 1221-1232.nb_NO
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/11250/2497423
dc.description.abstractBackground: The course of Alzheimer’s disease (AD) varies considerably between individuals. There is limited evidence on factors important for disease progression. Objective: The primary aim was to study the progression of AD, as measured by the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB). Secondary aims were to investigate whether baseline characteristics are important for differences in progression, and to examine the correlation between progression assessed using three different instruments: CDR-SB (0–18), the cognitive test Mini-Mental State Examination (MMSE, 0–30), and the functional measure Instrumental Activities of Daily Living (IADL, 0-1). Methods: The Progression of AD and Resource use (PADR) study is a longitudinal observational study in three Norwegian memory clinics. Results: In total, 282 AD patients (mean age 73.3 years, 54% female) were followed for mean 24 (16–37) months. The mean annual increase in CDR-SB was 1.6 (SD 1.8), the mean decrease in MMSE score 1.9 (SD 2.6), and the mean decrease in IADL score 0.13 (SD 0.14). Of the 282 patients, 132 (46.8%) progressed slowly, with less than 1 point yearly increase in CDR-SB. Cognitive test results at baseline predicted progression rate, and together with age, ApoE, history of hypertension, and drug use could explain 17% of the variance in progression rate. The strongest correlation of change was found between CDR-SB and IADL scores, the weakest between MMSE and IADL scores. Conclusion: Progression rate varied considerably among AD patients; about half of the patients progressed slowly. Cognitive test results at baseline were predictors of progression rate.nb_NO
dc.language.isoengnb_NO
dc.publisherIOS Pressnb_NO
dc.subjectDemensnb_NO
dc.subjectDementianb_NO
dc.subjectAlzheimers sykdomnb_NO
dc.subjectAlzheimer's diseasenb_NO
dc.titleProgression of Alzheimer's Disease: A Longitudinal Study in Norwegian Memory Clinicsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.subject.nsiVDP::Klinisk medisinske fag: 750nb_NO
dc.subject.nsiVDP::Clinical medical sciences: 750nb_NO
dc.source.pagenumber1221-1232nb_NO
dc.source.volume61nb_NO
dc.source.journalJournal of Alzheimer's Diseasenb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.3233/JAD-170436
dc.identifier.cristin1533856
dc.description.localcode© 2018 – IOS Press and the authors. All rights reserved.nb_NO
cristin.unitcode194,65,30,0
cristin.unitcode194,65,20,0
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel