Simple generalized reaction conditions for the conversion of primary aliphatic amines to surfactant-like guanidine salts with 1H-pyrazole carboxamidine hydrochloride
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OriginalversjonSynthetic Communications. 2017, 47 (2), 169-172. 10.1080/00397911.2016.1257724
Improved reaction conditions for the electrophile reaction between a free aliphatic amine and 1H-pyrazole carboxamidine have been discovered. The surfactant-like guanidine salts, which are often hard to work with, were obtained in decent yield with short reaction times, minimal workup, and high level of purity.