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dc.contributor.authorKumar, Rajesh
dc.contributor.authorPierce, David M.
dc.contributor.authorIsaksen, vidar
dc.contributor.authorDavies, Catharina de Lange
dc.contributor.authorDrogset, Jon Olav
dc.contributor.authorLilledahl, Magnus Borstad
dc.description.abstractOsteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular cartilage in clinically defined osteoarthritic stages may have importance in diagnosis and prognosis of OA. In this study we investigated differences in the biomechanical responses among human cartilage of ICRS grades I, II and III using polymer dynamics theory. We collected 24 explants of human articular cartilage (eight each of ICRS grade I, II and III) and acquired stress-relaxation data applying a continuous load on the articular surface of each cartilage explant for 1180 s. We observed a significant decrease in Young’s modulus, stress-relaxation time, and stretching exponent in advanced stages of OA (ICRS grade III). The stretch exponential model speculated that significant loss in hyaluronic acid polymer might be the reason for the loss of proteoglycan in advanced OA. This work encourages further biomechanical modelling of osteoarthritic cartilage utilizing these data as input parameters to enhance the fidelity of computational models aimed at revealing how mechanical behaviors play a role in pathogenesis of OA.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleComparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilagenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalInternational Journal of Molecular Sciencesnb_NO
dc.relation.projectSamarbeidsorganet mellom Helse Midt-Norge og NTNU: 46084300nb_NO
dc.relation.projectRegionale forskningsfond Midt-Norge: 46084300nb_NO
dc.description.localcode© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
cristin.unitnameInstitutt for fysikk
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal