dc.contributor.author | Ye, Jing | |
dc.contributor.author | Witter, Menno | |
dc.contributor.author | Moser, May-Britt | |
dc.contributor.author | Moser, Edvard Ingjald | |
dc.date.accessioned | 2018-02-28T14:15:15Z | |
dc.date.available | 2018-02-28T14:15:15Z | |
dc.date.created | 2018-02-08T09:56:04Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.uri | http://hdl.handle.net/11250/2487814 | |
dc.description.abstract | The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in a way that reflects ongoing movement in the environment, they must be able to read out the current speed of the animal. Speed is encoded by speed-responsive cells in both MEC and hippocampus, but the relationship between the two populations has not been determined. We show here that many entorhinal speed cells are fast-spiking putative GABAergic neurons. Using retrograde viral labeling from the hippocampus, we find that a subset of these fast-spiking MEC speed cells project directly to hippocampal areas. This projection contains parvalbumin (PV) but not somatostatin (SOM)-immunopositive cells. The data point to PV-expressing GABAergic projection neurons in MEC as a source for widespread speed modulation and temporal synchronization in entorhinal–hippocampal circuits for place representation. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | National Academy of Sciences | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Entorhinal fast-spiking speed cells project to the hippocampus | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.journal | Proceedings of the National Academy of Sciences of the United States of America | nb_NO |
dc.identifier.doi | 10.1073/pnas.1720855115 | |
dc.identifier.cristin | 1563082 | |
dc.description.localcode | Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,65,60,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Kavliinstitutt for nevrovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |