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Bariatric surgery versus lifestyle interventions for severe obesity: 5-year changes in body weight, risk factors and comorbidities

Øvrebø, Bente; Strømmen, Magnus; Kulseng, Bård Eirik; Martins, Catia
Journal article, Peer reviewed
Accepted version
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URI
http://hdl.handle.net/11250/2486786
Date
2017
Metadata
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  • Institutt for klinisk og molekylær medisin [2004]
  • Institutt for nevromedisin og bevegelsesvitenskap [1645]
  • Publikasjoner fra CRIStin - NTNU [19744]
Original version
Clinical Obesity. 2017, 7 (3), 183-190.   10.1111/cob.12190
Abstract
Changes in body weight (BW), risk factors and comorbidities 5 years after Roux-en-Y gastric bypass (RYGB) or different lifestyle interventions are compared. A total of 209 (75% women) severe obese adults were non-randomly allocated to: (A) RYGB (n = 58), (B) weight loss (WL) camp (n = 30), (C) residential intermittent programme (n = 64) or (D) hospital outpatient programme (n = 57). Body weight, risk factors and comorbidities were assessed at baseline, 1 and 5 years. A total of 89 and 54% completed the 1- and 5-year follow-up. The RYGB group experienced more WL at 5 years (−23.9%, 95% CI [−27.7, −20.0]) compared with lifestyle groups: (B) (−9.2%, 95% CI [−16.9, −1.5]), (C) (−4.1%, 95% CI [−8.0, −0.1]) and (D) (−4.1 kg, 95% CI [−10.0, 1.8]) (all P < 0.001). No differences were observed between lifestyle groups, although groups B and C had significant WL after 5 years (all P < 0.05). Plasma glucose and high-density lipoprotein cholesterol were improved in the RYGB group at 5 years compared with lifestyle groups (all P < 0.05). More patients in the RYGB group experienced remission of hypertension (P < 0.05). RYGB was associated with a lower BW, improved blood parameters and hypertension remission compared with lifestyle interventions at 5 years. However, significant WL was also achieved with lifestyle interventions.
Publisher
Wiley
Journal
Clinical Obesity

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