dc.contributor.author | Braadland, Peder | |
dc.contributor.author | Giskeødegård, Guro F. | |
dc.contributor.author | Sandsmark, Elise | |
dc.contributor.author | Bertilsson, Helena | |
dc.contributor.author | Euceda, Leslie R. | |
dc.contributor.author | Hansen, Ailin Falkmo | |
dc.contributor.author | Guldvik, Ingrid Jenny | |
dc.contributor.author | Selnæs, Kirsten Margrete | |
dc.contributor.author | Grytli, Helene Hartvedt | |
dc.contributor.author | Katz, Betina | |
dc.contributor.author | Svindland, Aud | |
dc.contributor.author | Bathen, Tone Frost | |
dc.contributor.author | Eri, Lars Magne | |
dc.contributor.author | Nygård, Ståle | |
dc.contributor.author | Berge, Viktor | |
dc.contributor.author | Tasken, Kristin Austlid | |
dc.contributor.author | Tessem, May-Britt | |
dc.date.accessioned | 2018-01-18T13:47:37Z | |
dc.date.available | 2018-01-18T13:47:37Z | |
dc.date.created | 2017-12-18T17:59:16Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | British Journal of Cancer. 2017, 117 (11), 1656-1664. | nb_NO |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | http://hdl.handle.net/11250/2478175 | |
dc.description.abstract | Background:
Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution magic angle spinning magnetic resonance spectroscopy (HR-MAS MRS) were associated with recurrence following radical prostatectomy.
Methods:
We performed a retrospective ex vivo study using HR-MAS MRS on tissue samples from 110 radical prostatectomy specimens obtained from three different Norwegian cohorts collected between 2002 and 2010. At the time of analysis, 50 patients had experienced prostate cancer recurrence. Associations between metabolites, clinicopathological variables, and recurrence-free survival were evaluated using Cox proportional hazards regression modelling, Kaplan–Meier survival analyses and concordance index (C-index).
Results:
High intratumoural spermine and citrate concentrations were associated with longer recurrence-free survival, whereas high (total-choline+creatine)/spermine (tChoCre/Spm) and higher (total-choline+creatine)/citrate (tChoCre/Cit) ratios were associated with shorter time to recurrence. Spermine concentration and tChoCre/Spm were independently associated with recurrence in multivariate Cox proportional hazards modelling after adjusting for clinically relevant risk factors (C-index: 0.769; HR: 0.72; P=0.016 and C-index: 0.765; HR: 1.43; P=0.014, respectively).
Conclusions:
Spermine concentration and tChoCre/Spm ratio in prostatectomy specimens were independent prognostic markers of recurrence. These metabolites can be noninvasively measured in vivo and may thus offer predictive value to establish preoperative risk assessment nomograms. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Publishing Group | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.no | * |
dc.title | Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1656-1664 | nb_NO |
dc.source.volume | 117 | nb_NO |
dc.source.journal | British Journal of Cancer | nb_NO |
dc.source.issue | 11 | nb_NO |
dc.identifier.doi | 10.1038/bjc.2017.346 | |
dc.identifier.cristin | 1529272 | |
dc.description.localcode | r 2017 Cancer Research UK. All rights reserved 0007 – 0920/17. The authors' accepted and reviewed manuscript (post-print) is locked until 3 April 2018 due to copyright restrictions. The Publisher's version will become freely available on 3 October 2018 under a Creative Commons Attribution- NonCommercial-Share Alike 4.0 Unported License. | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |