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dc.contributor.authorSulheim, Einar
dc.contributor.authorIversen, Tore Geir
dc.contributor.authorTo, Vu
dc.contributor.authorKlinkenberg, Geir
dc.contributor.authorSletta, Håvard
dc.contributor.authorSchmid, Ruth
dc.contributor.authorHatletveit, Anne Rein
dc.contributor.authorWågbø, Ane Marit
dc.contributor.authorSundan, Anders
dc.contributor.authorSkotland, Tore
dc.contributor.authorSandvig, Kirsten
dc.contributor.authorMørch, Ýrr Asbjørg
dc.date.accessioned2018-01-08T09:13:04Z
dc.date.available2018-01-08T09:13:04Z
dc.date.created2017-12-22T14:20:38Z
dc.date.issued2017
dc.identifier.citationInternational Journal of Molecular Sciences. 2017, 18 (11:2454), 1-17.nb_NO
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11250/2476117
dc.description.abstractAlthough nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated in several cell lines with different methods and on multiple nanoparticle batches. Here we report the toxicity of poly(alkyl cyanoacrylate) nanoparticles in 12 different cell lines after synthesizing and analyzing 19 different nanoparticle batches and report that large variations were obtained when using different cell lines or various toxicity assays. Surprisingly, we found that nanoparticles with intermediate degradation rates were less toxic than particles that were degraded faster or more slowly in a cell-free system. The toxicity did not vary significantly with either the three different combinations of polyethylene glycol surfactants or with particle size (range 100–200 nm). No acute pro- or anti-inflammatory activity on cells in whole blood was observed.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCytotoxicity of poly(Alkyl cyanoacrylate) nanoparticlesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-17nb_NO
dc.source.volume18nb_NO
dc.source.journalInternational Journal of Molecular Sciencesnb_NO
dc.source.issue11:2454nb_NO
dc.identifier.doi10.3390/ijms18112454
dc.identifier.cristin1531632
dc.relation.projectNorges forskningsråd: 228200/O70nb_NO
dc.relation.projectNorges forskningsråd: 179571nb_NO
dc.description.localcode© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,66,20,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for fysikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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