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dc.contributor.authorHeggelund, Jørn
dc.contributor.authorMorken, Gunnar
dc.contributor.authorHelgerud, Jan
dc.contributor.authorNilsberg, Geir Erling
dc.contributor.authorHoff, Jan
dc.description.abstractBackground Patients with schizophrenia frequently have disabling gait deficits. The net mechanical efficiency of walking (ϵ net ) is an accurate measure often used to evaluate walking performance. Patients with gait deficits have a reduced ϵ net with excessive energy expenditure during sub-maximal walking. Maximal strength training (MST) improves ϵ net in healthy individuals and is associated with reduced risk of mortality. The aim of this study was to investigate whether MST improves ϵ net in patients with schizophrenia. Methods Patients (ICD-10 schizophrenia, schizotypal or delusional disorders (F20-F29)) were included in a non-randomized trial. Patients were assigned to one of two groups: 1) MST consisting of 4x4 repetitions at 85-90% one repetition maximum (1RM) performed in a leg press apparatus or 2) playing computer games (CG). Both groups carried out their activity three days per week for eight weeks. 1RM, ϵ net at 60 watt walking, peak oxygen uptake (VO2peak), the Positive and Negative Syndrome Scale (PANSS) and the 36-items short form (SF-36) were measured pre and post intervention. Results The baseline ϵ net was 17.3 ± 1.2% and 19.4 ± 3.0% in the MST (n = 6) and CG groups (n = 7), respectively, which is categorized as mechanical inefficiency. The MST group improved 1RM by 79 kg (p = 0.006) and ϵ net by 3.4% (p = 0.046) more than the CG group. The MST group improved 1RM and ϵ net , by a mean of 83 kg (p = 0.028) and 3.4% (p = 0.028), respectively. VO2peak at baseline was 34.2 ± 10.2 and 38.3 ± 9.8 ml·kg-1·min-1 in the MST and CG groups, respectively, and did not change (p > 0.05). No change was observed in PANSS or SF-36 (p > 0.05). Conclusions MST improves 1RM and ϵ net in patients with schizophrenia. MST could be used as a therapeutic intervention for patients with schizophrenia to normalize their reduced ϵ net .nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleTherapeutic effects of maximal strength training on walking efficiency in patients with schizophrenia - a pilot studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMC Research Notesnb_NO
dc.description.localcode© 2012 Heggelund et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameInstitutt for psykisk helse
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal