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dc.contributor.authorZhao, Yiming
dc.contributor.authorFay, Francois
dc.contributor.authorHak, Sjoerd
dc.contributor.authorManuel Perez-Aguilar, Jose
dc.contributor.authorSanchez-Gaytan, Brenda L
dc.contributor.authorGoode, Brandon
dc.contributor.authorDuivenvoorden, Raphael
dc.contributor.authorDavies, Ruth Catharina de Lange
dc.contributor.authorBjørkøy, Astrid
dc.contributor.authorWeinstein, Harel
dc.contributor.authorFayad, Zahi A
dc.contributor.authorPerez-Medina, Carlos
dc.contributor.authorMulder, Willem J M
dc.date.accessioned2018-01-03T08:59:21Z
dc.date.available2018-01-03T08:59:21Z
dc.date.created2016-09-27T09:29:48Z
dc.date.issued2016
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11250/2474226
dc.description.abstractA major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model. We found the drug’s hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug’s compatibility; as a result, we achieved better antitumour efficacy. Our results help elucidate nanomedicines’ in vivo fate and provide guidelines for efficient drug delivery.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAugmenting drug-carrier compatibility improves tumour nanotherapy efficacynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume7nb_NO
dc.source.journalNature Communicationsnb_NO
dc.identifier.doi10.1038/ncomms11221
dc.identifier.cristin1386026
dc.relation.projectNorges forskningsråd: 230788nb_NO
dc.description.localcode© 2016 The Authors. Published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License.nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,66,20,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for fysikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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