dc.contributor.author | Sugar, Jørgen | |
dc.contributor.author | Witter, Menno | |
dc.date.accessioned | 2018-01-03T08:45:53Z | |
dc.date.available | 2018-01-03T08:45:53Z | |
dc.date.created | 2016-10-13T13:02:53Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | eLIFE. 2016, 5:e13925. | nb_NO |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | http://hdl.handle.net/11250/2474213 | |
dc.description.abstract | The rat parahippocampal region (PHR) and retrosplenial cortex (RSC) are cortical areas important for spatial cognition. In PHR, head-direction cells are present before eye-opening, earliest detected in postnatal day (P)11 animals. Border cells have been recorded around eye-opening (P16), while grid cells do not obtain adult-like features until the fourth postnatal week. In view of these developmental time-lines, we aimed to explore when afferents originating in RSC arrive in PHR. To this end, we injected rats aged P0-P28 with anterograde tracers into RSC. First, we characterized the organization of RSC-PHR projections in postnatal rats and compared these results with data obtained in the adult. Second, we described the morphological development of axonal plexus in PHR. We conclude that the first arriving RSC-axons in PHR, present from P1 onwards, already show a topographical organization similar to that seen in adults, although the labeled plexus does not obtain adult-like densities until P12. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | eLife Sciences Publications | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Postnatal development of retrosplenial projections to the parahippocampal region of the rat | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 29 | nb_NO |
dc.source.volume | 5 | nb_NO |
dc.source.journal | eLIFE | nb_NO |
dc.source.issue | 2016 | nb_NO |
dc.identifier.doi | 10.7554/eLife.13925 | |
dc.identifier.cristin | 1391489 | |
dc.relation.project | Norges forskningsråd: Centre for Excellence grant | nb_NO |
dc.relation.project | Kavli Foundation: Prosjekt: 47062003 | nb_NO |
dc.relation.project | Norges forskningsråd: 223262(Grant reference number 145993) | nb_NO |
dc.relation.project | Norges forskningsråd: 223262(Grant reference number 181676) | nb_NO |
dc.description.localcode | Copyright Sugar and Witter. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | nb_NO |
cristin.unitcode | 194,65,60,0 | |
cristin.unitname | Kavliinstitutt for nevrovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |