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dc.contributor.authorSugar, Jørgen
dc.contributor.authorWitter, Menno
dc.date.accessioned2018-01-03T08:45:53Z
dc.date.available2018-01-03T08:45:53Z
dc.date.created2016-10-13T13:02:53Z
dc.date.issued2016
dc.identifier.citationeLIFE. 2016, 5:e13925.nb_NO
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11250/2474213
dc.description.abstractThe rat parahippocampal region (PHR) and retrosplenial cortex (RSC) are cortical areas important for spatial cognition. In PHR, head-direction cells are present before eye-opening, earliest detected in postnatal day (P)11 animals. Border cells have been recorded around eye-opening (P16), while grid cells do not obtain adult-like features until the fourth postnatal week. In view of these developmental time-lines, we aimed to explore when afferents originating in RSC arrive in PHR. To this end, we injected rats aged P0-P28 with anterograde tracers into RSC. First, we characterized the organization of RSC-PHR projections in postnatal rats and compared these results with data obtained in the adult. Second, we described the morphological development of axonal plexus in PHR. We conclude that the first arriving RSC-axons in PHR, present from P1 onwards, already show a topographical organization similar to that seen in adults, although the labeled plexus does not obtain adult-like densities until P12.nb_NO
dc.language.isoengnb_NO
dc.publishereLife Sciences Publicationsnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePostnatal development of retrosplenial projections to the parahippocampal region of the ratnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber29nb_NO
dc.source.volume5nb_NO
dc.source.journaleLIFEnb_NO
dc.source.issue2016nb_NO
dc.identifier.doi10.7554/eLife.13925
dc.identifier.cristin1391489
dc.relation.projectNorges forskningsråd: Centre for Excellence grantnb_NO
dc.relation.projectKavli Foundation: Prosjekt: 47062003nb_NO
dc.relation.projectNorges forskningsråd: 223262(Grant reference number 145993)nb_NO
dc.relation.projectNorges forskningsråd: 223262(Grant reference number 181676)nb_NO
dc.description.localcodeCopyright Sugar and Witter. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.nb_NO
cristin.unitcode194,65,60,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal