Vis enkel innførsel

dc.contributor.authorRye, Morten Beck
dc.contributor.authorSandve, Geir Kjetil F.
dc.contributor.authorDaub, Carsten O
dc.contributor.authorKawaji, H
dc.contributor.authorCarninci, P
dc.contributor.authorForrest, A
dc.contributor.authorDrabløs, Finn
dc.date.accessioned2018-01-02T12:15:04Z
dc.date.available2018-01-02T12:15:04Z
dc.date.created2014-10-15T14:28:22Z
dc.date.issued2014
dc.identifier.citationBMC Genomics. 2014, 15 (120).nb_NO
dc.identifier.issn1471-2164
dc.identifier.urihttp://hdl.handle.net/11250/2474028
dc.description.abstractBackground Deciphering the most common modes by which chromatin regulates transcription, and how this is related to cellular status and processes is an important task for improving our understanding of human cellular biology. The FANTOM5 and ENCODE projects represent two independent large scale efforts to map regulatory and transcriptional features to the human genome. Here we investigate chromatin features around a comprehensive set of transcription start sites in four cell lines by integrating data from these two projects. Results Transcription start sites can be distinguished by chromatin states defined by specific combinations of both chromatin mark enrichment and the profile shapes of these chromatin marks. The observed patterns can be associated with cellular functions and processes, and they also show association with expression level, location relative to nearby genes, and CpG content. In particular we find a substantial number of repressed inter- and intra-genic transcription start sites enriched for active chromatin marks and Pol II, and these sites are strongly associated with immediate-early response processes and cell signaling. Associations between start sites with similar chromatin patterns are validated by significant correlations in their global expression profiles. Conclusions The results confirm the link between chromatin state and cellular function for expressed transcripts, and also indicate that active chromatin states at repressed transcripts may poise transcripts for rapid activation during immune response.nb_NO
dc.language.isoengnb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleChromatin states reveal functional associations for globally defined transcription start sites in four human cell linesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume15nb_NO
dc.source.journalBMC Genomicsnb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1186/1471-2164-15-120
dc.identifier.cristin1164247
dc.relation.projectNorges forskningsråd: 174826nb_NO
dc.description.localcode© 2014 Rye et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal