dc.contributor.author | Tang, Clara S. | |
dc.contributor.author | Zhang, He | |
dc.contributor.author | Cheung, Chloe Y.Y. | |
dc.contributor.author | Xu, Ming | |
dc.contributor.author | Ho, Jenny C.Y. | |
dc.contributor.author | Zhou, Wei | |
dc.contributor.author | Cherny, Stacey S. | |
dc.contributor.author | Zhang, Yan | |
dc.contributor.author | Holmen, Oddgeir | |
dc.contributor.author | Au, Ka-Wing | |
dc.contributor.author | Yu, Haiyi | |
dc.contributor.author | Xu, Lin | |
dc.contributor.author | Jia, Jia | |
dc.contributor.author | Porsch, Robert M. | |
dc.contributor.author | Sun, Lijie | |
dc.contributor.author | Xu, Weixian | |
dc.contributor.author | Zheng, Huiping | |
dc.contributor.author | Wong, Lai-Yung | |
dc.contributor.author | Mu, Yiming | |
dc.contributor.author | Dou, Jingtao | |
dc.contributor.author | Fong, Carol H.Y. | |
dc.contributor.author | Wang, Shuyu | |
dc.contributor.author | Hong, Xueyu | |
dc.contributor.author | Dong, Liguang | |
dc.contributor.author | Liao, Yanhua | |
dc.contributor.author | Wang, Jiansong | |
dc.contributor.author | Lam, Levina S.M. | |
dc.contributor.author | Su, Xi | |
dc.contributor.author | Yan, Hua | |
dc.contributor.author | Yang, Min-Lee | |
dc.contributor.author | Chen, Jin | |
dc.contributor.author | Siu, Chung-Wah | |
dc.contributor.author | Xie, Gaoqiang | |
dc.contributor.author | Woo, Yu-Cho | |
dc.contributor.author | Wu, Yangfeng | |
dc.contributor.author | Tan, Kathryn C.B. | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Cheung, Bernard M.Y. | |
dc.contributor.author | Zöllner, Sebastian | |
dc.contributor.author | Xu, Aimin | |
dc.contributor.author | Chen, Y. Eugene | |
dc.contributor.author | Jiang, Chao Qiang | |
dc.contributor.author | Zhang, Youyi | |
dc.contributor.author | Lam, Tai-Hing | |
dc.contributor.author | Ganesh, Santhi K. | |
dc.contributor.author | Huo, Yong | |
dc.contributor.author | Sham, Pak C. | |
dc.contributor.author | Lam, Karen S.L. | |
dc.contributor.author | Willer, Cristen J. | |
dc.contributor.author | Tse, Hung-Fat | |
dc.contributor.author | Gao, Wei | |
dc.date.accessioned | 2018-01-02T12:05:18Z | |
dc.date.available | 2018-01-02T12:05:18Z | |
dc.date.created | 2016-01-21T13:47:50Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Nature Communications. 2015, 6:10206 . | nb_NO |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/11250/2474017 | |
dc.description.abstract | Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P<2.69 × 10−7), including three Asian-specific coding variants in known genes (CETP p.Asp459Gly, PCSK9 p.Arg93Cys and LDLR p.Arg257Trp). Furthermore, missense variants at two novel loci—PNPLA3 p.Ile148Met and PKD1L3 p.Thr429Ser—also influence levels of triglycerides and low-density lipoprotein cholesterol, respectively. Another novel gene, TEAD2, is found to be associated with high-density lipoprotein cholesterol through gene-based association analysis. Most of these newly identified coding variants show suggestive association (P<0.05) with CAD. These findings demonstrate that exome-wide genotyping on samples of non-European ancestry can identify additional population-specific possible causal variants, shedding light on novel lipid biology and CAD. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.relation.uri | http://www.nature.com/ncomms/2015/151222/ncomms10206/pdf/ncomms10206.pdf | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 9 | nb_NO |
dc.source.volume | 6:10206 | nb_NO |
dc.source.journal | Nature Communications | nb_NO |
dc.identifier.doi | 10.1038/ncomms10206 | |
dc.identifier.cristin | 1319468 | |
dc.relation.project | Norges forskningsråd: 220964 | nb_NO |
dc.description.localcode | © 2015 The Authors. Published by Nature Publishing Group. This is an open access article licensed under a Creative Commons Attribution 4.0 International License | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |