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L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles

McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm
Journal article, Peer reviewed
Accepted version
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URI
http://hdl.handle.net/11250/2468789
Date
2016
Metadata
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  • Institutt for kjemisk prosessteknologi [1206]
  • Institutt for materialteknologi [1561]
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  • Institutt for sirkulasjon og bildediagnostikk [1007]
  • Publikasjoner fra CRIStin - NTNU [19694]
Original version
Small. 2016, 12 (3), 301-306.   10.1002/smll.201502545
Abstract
Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn2+ and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.
Publisher
Wiley
Journal
Small

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