dc.contributor.author | Mørch, Ýrr Asbjørg | |
dc.contributor.author | Hansen, Rune | |
dc.contributor.author | Berg, Sigrid | |
dc.contributor.author | Åslund, Andreas | |
dc.contributor.author | Glomm, Wilhelm | |
dc.contributor.author | Eggen, Siv | |
dc.contributor.author | Schmid, Ruth | |
dc.contributor.author | Johnsen, Heidi | |
dc.contributor.author | Kubowicz, Stephan | |
dc.contributor.author | Snipstad, Sofie | |
dc.contributor.author | Sulheim, Einar | |
dc.contributor.author | Hak, Sjoerd | |
dc.contributor.author | Singh, Gurvinder | |
dc.contributor.author | McDonagh, Birgitte Hjelmeland | |
dc.contributor.author | Blom, Hans | |
dc.contributor.author | Davies, Ruth Catharina de Lange | |
dc.contributor.author | Stenstad, Per Martin | |
dc.date.accessioned | 2017-10-31T08:46:29Z | |
dc.date.available | 2017-10-31T08:46:29Z | |
dc.date.created | 2015-11-19T08:47:18Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Contrast Media & Molecular Imaging. 2015, 10 (5), 356-366. | nb_NO |
dc.identifier.issn | 1555-4309 | |
dc.identifier.uri | http://hdl.handle.net/11250/2463066 | |
dc.description.abstract | Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG)-coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self-assembly of NPs at the MB air–liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NP–MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue, providing improved therapy and imaging contrast compared with freely distributed NPs. Copyright © 2015 John Wiley & Sons, Ltd. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.title | Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery | nb_NO |
dc.type | Journal article | nb_NO |
dc.description.version | submittedVersion | nb_NO |
dc.source.pagenumber | 356-366 | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | Contrast Media & Molecular Imaging | nb_NO |
dc.source.issue | 5 | nb_NO |
dc.identifier.doi | 10.1002/cmmi.1639 | |
dc.identifier.cristin | 1290664 | |
dc.relation.project | Samarbeidsorganet mellom Helse Midt-Norge og NTNU: | nb_NO |
dc.relation.project | Norges forskningsråd: 220005 | nb_NO |
dc.description.localcode | This is the pre-peer reviewed version of the following article: [Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1639/abstract]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,66,20,0 | |
cristin.unitcode | 194,66,30,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for fysikk | |
cristin.unitname | Institutt for kjemisk prosessteknologi | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.qualitycode | 1 | |