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dc.contributor.authorAarstad, Olav Andreas
dc.contributor.authorHeggset, Ellinor Bævre
dc.contributor.authorPedersen, Ina S.
dc.contributor.authorBjørnøy, Sindre Hove
dc.contributor.authorSyverud, Kristin
dc.contributor.authorStrand, Berit Løkensgard
dc.date.accessioned2017-10-30T12:01:24Z
dc.date.available2017-10-30T12:01:24Z
dc.date.created2017-08-22T16:09:05Z
dc.date.issued2017
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/11250/2462856
dc.description.abstractAlginate and cellulose nanofibrils (CNF) are attractive materials for tissue engineering and regenerative medicine. CNF gels are generally weaker and more brittle than alginate gels, while alginate gels are elastic and have high rupture strength. Alginate properties depend on their guluronan and mannuronan content and their sequence pattern and molecular weight. Likewise, CNF exists in various qualities with properties depending on, e.g., morphology and charge density. In this study combinations of three types of alginate with different composition and two types of CNF with different charge and degree of fibrillation have been studied. Assessments of the composite gels revealed that attractive properties like high rupture strength, high compressibility, high gel rigidity at small deformations (Young’s modulus), and low syneresis was obtained compared to the pure gels. The effects varied with relative amounts of CNF and alginate, alginate type, and CNF quality. The largest effects were obtained by combining oxidized CNF with the alginates. Hence, by combining the two biopolymers in composite gels, it is possible to tune the rupture strength, Young’s modulus, syneresis, as well as stability in physiological saline solution, which are all important properties for the use as scaffolds in tissue engineering.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMechanical properties of composite hydrogels of alginate and cellulose nanofibrilsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume9nb_NO
dc.source.journalPolymersnb_NO
dc.source.issue8nb_NO
dc.identifier.doi10.3390/polym9080378
dc.identifier.cristin1487960
dc.relation.projectNorges forskningsråd: 228147nb_NO
dc.relation.projectNorges forskningsråd: 221576nb_NO
dc.description.localcode(c) 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,66,15,0
cristin.unitcode194,66,20,0
cristin.unitcode194,66,30,0
cristin.unitnameInstitutt for bioteknologi og matvitenskap
cristin.unitnameInstitutt for fysikk
cristin.unitnameInstitutt for kjemisk prosessteknologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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