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dc.contributor.authorTangerås, Line Haugstad
dc.contributor.authorAustdal, Marie
dc.contributor.authorSkråstad, Ragnhild
dc.contributor.authorSalvesen, Kjell Å
dc.contributor.authorAustgulen, Rigmor
dc.contributor.authorBathen, Tone Frost
dc.contributor.authorIversen, Ann-Charlotte
dc.date.accessioned2017-10-02T06:59:15Z
dc.date.available2017-10-02T06:59:15Z
dc.date.created2015-09-14T10:41:14Z
dc.date.issued2015
dc.identifier.citationArteriosclerosis, Thrombosis and Vascular Biology. 2015, 35 (11), 2478-2485.nb_NO
dc.identifier.issn1079-5642
dc.identifier.urihttp://hdl.handle.net/11250/2457598
dc.description.abstractObjective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate disease-specific early pregnancy serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia for new insight into the underlying pathogeneses and differences between the disorders. Approach and Results—The study cohort consisted of 548 pregnant Norwegian women who were either multiparous with previous gestational hypertension or preeclampsia or were nulliparous. Maternal sera at gestational weeks 110–136 were assayed for 27 cytokines, C-reactive protein, total cholesterol, high-density lipoprotein, triglyceride, creatinine, calcium, uric acid, and placental growth factor. Compared with normotensive women, women with both hypertensive conditions presented an atherogenic lipid profile at early gestation, but only those later developing gestational hypertension had significantly higher serum levels of interleukin (IL)-5 and IL-12. Comparing the 2 hypertensive pregnancy disorders, women subsequently developing gestational hypertension had higher serum levels of IL-1β, IL-5, IL-7, IL-8, IL-13, basic fibroblast growth factor, and vascular endothelial growth factor than the women subsequently developing preeclampsia. Conclusions—This study identifies early pregnancy differences in serum cytokine profiles for gestational hypertension and preeclampsia.nb_NO
dc.language.isoengnb_NO
dc.publisherAmerican Heart Associationnb_NO
dc.titleDistinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsianb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber2478-2485nb_NO
dc.source.volume35nb_NO
dc.source.journalArteriosclerosis, Thrombosis and Vascular Biologynb_NO
dc.source.issue11nb_NO
dc.identifier.doi10.1161/ATVBAHA.115.305817
dc.identifier.cristin1263891
dc.relation.projectNorges forskningsråd: 205400nb_NO
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcode© 2015. This is the authors’ accepted and refereed manuscript to an article published by American Heart Association, Incnb_NO
cristin.unitcode194,65,15,30
cristin.unitcode194,65,15,0
cristin.unitcode194,65,25,0
cristin.unitcode194,65,10,0
cristin.unitnameCentre of Molecular Inflammation Research (SFF-CEMIR)
cristin.unitnameInstitutt for kreftforskning og molekylær medisin
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for laboratoriemedisin, barne- og kvinnesykdommer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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