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Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia

Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte
Journal article, Peer reviewed
Accepted version
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HLA-G+manuscript+Pabalan+et+al+2015.pdf (804.4Kb)
Permanent lenke
http://hdl.handle.net/11250/2456285
Utgivelsesdato
2015
Metadata
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  • Institutt for klinisk og molekylær medisin [2072]
  • Publikasjoner fra CRIStin - NTNU [21000]
Originalversjon
Tissue Antigens. 2015, 86 (3), 186-194.   10.1111/tan.12627
Sammendrag
The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the uterine wall, to ensure successful placental development and function. Several HLA-G gene variants have been shown to be associated with development of preeclampsia (PE), but the reported associations of the HLA-G 14bp (base pair) insertion/deletion (I/D) polymorphism (rs66554220) with PE are inconsistent. In this meta-analysis of HLA-G 14bp I/D in each member of the family triad, we estimated risk (odds ratio [OR], 95% confidence interval) of associations with PE based on nine published offspring, nine mother and three father case-control studies.

No significant increased risk associations between PE and HLA-G 14bp I/D were detected in any of the family triad members (offspring: OR = 1.08-1.21, P = 0.57-0.74; mothers: OR = 1.11-1.28, P = 0.07-0.44; fathers: OR = 1.09-1.65, P = 0.07-0.70). Of the 20 comparisons performed, 14 (70%) were non-heterogeneous and seven of these had zero heterogeneity (I 2 = 0%). Sensitivity treatment confirmed robustness for the overall lack of association for HLA-G 14bp I/D. In subgroup analysis, significant association between HLA-G 14bp I/D and PE was shown in offspring from primipara (OR = 1.66-1.95, P = 0.04) and European Caucasian pregnancies (OR = 1.37-2.03, P = 0.02-0.03). However, heterogeneity and sensitivity tests suggest that further investigation is needed to determine if HLA-G 14bp I/D is involved in trophoblast HLA-G expression and PE development in these subgroups
Utgiver
Wiley
Tidsskrift
Tissue Antigens

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