dc.contributor.author | Pabalan, Noel | |
dc.contributor.author | Jarjanazi, H | |
dc.contributor.author | Sun, Chen | |
dc.contributor.author | Iversen, Ann-Charlotte | |
dc.date.accessioned | 2017-09-22T12:02:49Z | |
dc.date.available | 2017-09-22T12:02:49Z | |
dc.date.created | 2015-09-14T10:27:22Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Tissue Antigens. 2015, 86 (3), 186-194. | nb_NO |
dc.identifier.issn | 0001-2815 | |
dc.identifier.uri | http://hdl.handle.net/11250/2456285 | |
dc.description.abstract | The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the uterine wall, to ensure successful placental development and function. Several HLA-G gene variants have been shown to be associated with development of preeclampsia (PE), but the reported associations of the HLA-G 14bp (base pair) insertion/deletion (I/D) polymorphism (rs66554220) with PE are inconsistent. In this meta-analysis of HLA-G 14bp I/D in each member of the family triad, we estimated risk (odds ratio [OR], 95% confidence interval) of associations with PE based on nine published offspring, nine mother and three father case-control studies.
No significant increased risk associations between PE and HLA-G 14bp I/D were detected in any of the family triad members (offspring: OR = 1.08-1.21, P = 0.57-0.74; mothers: OR = 1.11-1.28, P = 0.07-0.44; fathers: OR = 1.09-1.65, P = 0.07-0.70). Of the 20 comparisons performed, 14 (70%) were non-heterogeneous and seven of these had zero heterogeneity (I 2 = 0%). Sensitivity treatment confirmed robustness for the overall lack of association for HLA-G 14bp I/D. In subgroup analysis, significant association between HLA-G 14bp I/D and PE was shown in offspring from primipara (OR = 1.66-1.95, P = 0.04) and European Caucasian pregnancies (OR = 1.37-2.03, P = 0.02-0.03). However, heterogeneity and sensitivity tests suggest that further investigation is needed to determine if HLA-G 14bp I/D is involved in trophoblast HLA-G expression and PE development in these subgroups | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.title | Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 186-194 | nb_NO |
dc.source.volume | 86 | nb_NO |
dc.source.journal | Tissue Antigens | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.1111/tan.12627 | |
dc.identifier.cristin | 1263883 | |
dc.relation.project | Norges forskningsråd: 205400 | nb_NO |
dc.relation.project | Norges forskningsråd: 223255 | nb_NO |
dc.description.localcode | This is the peer reviewed version of the following article: Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia, which has been published in final form at 10.1111/tan.12627. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving | |
cristin.unitcode | 194,65,15,30 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Centre of Molecular Inflammation Research (SFF-CEMIR) | |
cristin.unitname | Institutt for kreftforskning og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |