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dc.contributor.authorPabalan, Noel
dc.contributor.authorJarjanazi, H
dc.contributor.authorSun, Chen
dc.contributor.authorIversen, Ann-Charlotte
dc.date.accessioned2017-09-22T12:02:49Z
dc.date.available2017-09-22T12:02:49Z
dc.date.created2015-09-14T10:27:22Z
dc.date.issued2015
dc.identifier.citationTissue Antigens. 2015, 86 (3), 186-194.nb_NO
dc.identifier.issn0001-2815
dc.identifier.urihttp://hdl.handle.net/11250/2456285
dc.description.abstractThe non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the uterine wall, to ensure successful placental development and function. Several HLA-G gene variants have been shown to be associated with development of preeclampsia (PE), but the reported associations of the HLA-G 14bp (base pair) insertion/deletion (I/D) polymorphism (rs66554220) with PE are inconsistent. In this meta-analysis of HLA-G 14bp I/D in each member of the family triad, we estimated risk (odds ratio [OR], 95% confidence interval) of associations with PE based on nine published offspring, nine mother and three father case-control studies. No significant increased risk associations between PE and HLA-G 14bp I/D were detected in any of the family triad members (offspring: OR = 1.08-1.21, P = 0.57-0.74; mothers: OR = 1.11-1.28, P = 0.07-0.44; fathers: OR = 1.09-1.65, P = 0.07-0.70). Of the 20 comparisons performed, 14 (70%) were non-heterogeneous and seven of these had zero heterogeneity (I 2 = 0%). Sensitivity treatment confirmed robustness for the overall lack of association for HLA-G 14bp I/D. In subgroup analysis, significant association between HLA-G 14bp I/D and PE was shown in offspring from primipara (OR = 1.66-1.95, P = 0.04) and European Caucasian pregnancies (OR = 1.37-2.03, P = 0.02-0.03). However, heterogeneity and sensitivity tests suggest that further investigation is needed to determine if HLA-G 14bp I/D is involved in trophoblast HLA-G expression and PE development in these subgroupsnb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titleMeta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsianb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber186-194nb_NO
dc.source.volume86nb_NO
dc.source.journalTissue Antigensnb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.1111/tan.12627
dc.identifier.cristin1263883
dc.relation.projectNorges forskningsråd: 205400nb_NO
dc.relation.projectNorges forskningsråd: 223255nb_NO
dc.description.localcodeThis is the peer reviewed version of the following article: Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia, which has been published in final form at 10.1111/tan.12627. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
cristin.unitcode194,65,15,30
cristin.unitcode194,65,15,0
cristin.unitnameCentre of Molecular Inflammation Research (SFF-CEMIR)
cristin.unitnameInstitutt for kreftforskning og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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