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Evolution of the plasma proteome of divers before and after a single SCUBA dive

Lautridou, Jacky; Pichereau, Vianney; Artigaud, Sébastien; Bernay, Benoit; Barak, Otto; Hoiland, Ryan; Lovering, Andrew T; Eftedal, Ingrid; Dujic, Zeljko; Guerrero, François
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/2444376
Date
2017
Metadata
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  • Institutt for sirkulasjon og bildediagnostikk [1051]
  • Publikasjoner fra CRIStin - NTNU [20946]
Original version
10.1002/prca.201700016
Abstract
Purpose: Decompression sickness (DCS) is a poorly understood and complex systemic disease caused by inadequate desaturation following a reduction of ambient pressure. A previous proteomic study of ours showed that DCS occurrence but not diving was associated with changes in the plasma proteome in rats, including a dramatic decrease of abundance of the tetrameric form of Transthyretin (TTR). The present study aims to assess the impact on the human blood proteome of a dive inducing significant decompression stress but without inducing DCS symptoms. Experimental design: Twelve healthy male divers were subjected to a single dive at a depth of 18m of sea water (msw) with a 47-min bottom time followed by a direct ascent to the surface at a rate of 9msw/min. Venous blood was collected before the dive as well as 30mn and 2h following the dive. The plasma proteomes from four individuals were then analyzed by using a two-dimensional electrophoresis-based proteomic strategy. Results: No protein spot showed a significantly changed abundance (fdr< 0.1) between the tested times. Conclusion: These results strengthen the hypothesis according to which significant changes of the plasma proteome measurable with two-dimensional electrophoresis may only occur along with DCS symptoms.
Publisher
Wiley
Journal
PROTEOMICS - Clinical Applications

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