dc.contributor.author | Lautridou, Jacky | |
dc.contributor.author | Pichereau, Vianney | |
dc.contributor.author | Artigaud, Sébastien | |
dc.contributor.author | Bernay, Benoit | |
dc.contributor.author | Barak, Otto | |
dc.contributor.author | Hoiland, Ryan | |
dc.contributor.author | Lovering, Andrew T | |
dc.contributor.author | Eftedal, Ingrid | |
dc.contributor.author | Dujic, Zeljko | |
dc.contributor.author | Guerrero, François | |
dc.date.accessioned | 2017-06-06T07:48:57Z | |
dc.date.available | 2017-06-06T07:48:57Z | |
dc.date.created | 2017-04-20T15:03:02Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1862-8354 | |
dc.identifier.uri | http://hdl.handle.net/11250/2444376 | |
dc.description.abstract | Purpose: Decompression sickness (DCS) is a poorly understood and complex systemic disease caused by inadequate desaturation following a reduction of ambient pressure. A previous proteomic study of ours showed that DCS occurrence but not diving was associated with changes in the plasma proteome in rats, including a dramatic decrease of abundance of the tetrameric form of Transthyretin (TTR). The present study aims to assess the impact on the human blood proteome of a dive inducing significant decompression stress but without inducing DCS symptoms. Experimental design: Twelve healthy male divers were subjected to a single dive at a depth of 18m of sea water (msw) with a 47-min bottom time followed by a direct ascent to the surface at a rate of 9msw/min. Venous blood was collected before the dive as well as 30mn and 2h following the dive. The plasma proteomes from four individuals were then analyzed by using a two-dimensional electrophoresis-based proteomic strategy. Results: No protein spot showed a significantly changed abundance (fdr< 0.1) between the tested times. Conclusion: These results strengthen the hypothesis according to which significant changes of the plasma proteome measurable with two-dimensional electrophoresis may only occur along with DCS symptoms. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.title | Evolution of the plasma proteome of divers before and after a single SCUBA dive | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.source.journal | PROTEOMICS - Clinical Applications | nb_NO |
dc.identifier.doi | 10.1002/prca.201700016 | |
dc.identifier.cristin | 1465755 | |
dc.description.localcode | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the authors' accepted and refereed manuscript to the article. Locked until 12 May 2018 due to copyright restrictions | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |