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dc.contributor.authorLozano-Botellero, Violeta Nazaret
dc.contributor.authorSkranes, Jon Sverre
dc.contributor.authorBjuland, Knut Jørgen
dc.contributor.authorLøhaugen, Gro
dc.contributor.authorHåberg, Asta
dc.contributor.authorLydersen, Stian
dc.contributor.authorBrubakk, Ann-Mari
dc.contributor.authorIndredavik, Marit Sæbø
dc.contributor.authorMartinussen, Marit
dc.date.accessioned2016-11-09T10:45:41Z
dc.date.accessioned2016-11-14T09:24:13Z
dc.date.available2016-11-09T10:45:41Z
dc.date.available2016-11-14T09:24:13Z
dc.date.issued2016
dc.identifier.citationChild and Adolescent Psychiatry and Mental Health 2016, 10(6)nb_NO
dc.identifier.issn1753-2000
dc.identifier.urihttp://hdl.handle.net/11250/2420799
dc.description.abstractBackground: Preterm birth at very low birth weight (VLBW) poses a risk for cerebellar abnormalities and increased psychiatric morbidity compared with reference populations. We aimed to study cerebellar volumes (grey and white matter; GM, WM) and mental health in VLBW individuals and controls at 15 and 19 years of age, as well as changes between the two time points. Methods: Forty VLBW (≤1500 g) and 56 control adolescents were included in the study at 15 years of age, and 44 VLBW and 60 control adolescents at 19 years of age. We had longitudinal data for 30 VLBW participants and for 37 controls. Clinical diagnoses were assessed following the schedule for affective disorders and schizophrenia for school-age children (KSADS). Psychiatric symptoms and function were further investigated with the Achenbach System of Empirically Based Assessment (ASEBA), ADHD Rating Scale-IV and the children’s global assessment scale (CGAS). An automatic segmentation of cerebellar GM and WM volumes was performed in FreeSurfer. The MRI scans were obtained on the same 1.5T scanner at both ages. Results: The VLBW group had higher rates of psychiatric disorders at both ages. Cerebellar growth trajectories did not differ between VLBW adolescents and controls, regardless of psychiatric status. However, VLBW adolescents who had a psychiatric diagnosis at both ages or developed a psychiatric disorder from 15 to 19 years had maintained smaller cerebellar WM and GM volumes than controls and also smaller volumes than VLWB adolescents who were or became healthy in this period. Moreover, there were no differences in cerebellar WM and GM volumes between controls and those VLBW who were healthy or became healthy. In the VLBW group, cerebellar WM and GM volumes correlated positively with psycho-social function at both 15 and 19 years of age, and smaller GM volumes were associated with inattention at 15 years. Conclusions: Smaller cerebellar volume in adolescents born very preterm and with VLBW may be a biomarker of increased risk of psychiatric problems in young adulthood.nb_NO
dc.language.isoengnb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/no/*
dc.titleMental health and cerebellar volume during adolescence in very-low-birth-weight infants: A longitudinal studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2016-11-09T10:45:41Z
dc.source.volume10nb_NO
dc.source.journalChild and Adolescent Psychiatry and Mental Healthnb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.1186/s13034-016-0093-8
dc.identifier.cristin1353400
dc.relation.projectNotur/NorStore: NN9208Knb_NO
dc.description.localcode© Botellero et al. 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO


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