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dc.contributor.authorHagen, Knut
dc.contributor.authorPettersen, Elin
dc.contributor.authorStovner, Lars Jacob
dc.contributor.authorSkorpen, Frank
dc.contributor.authorZwart, John-Anker
dc.identifier.citationBMC Musculoskeletal Disorders 2006, 4:7-40nb_NO
dc.description.abstractBackground: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. Methods: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/ Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals. Results: The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups. Conclusion: In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.titleNo association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMC Musculoskeletal Disordersnb_NO
dc.description.localcode© 2006 Hagen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO

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