dc.contributor.author | Johnsen, Anne Berit | |
dc.contributor.author | Høydal, Morten Andre | |
dc.contributor.author | Røsbjørgen, Ragnhild | |
dc.contributor.author | Stølen, Tomas | |
dc.contributor.author | Wisløff, Ulrik | |
dc.date.accessioned | 2015-11-20T11:01:00Z | |
dc.date.accessioned | 2016-06-02T11:52:29Z | |
dc.date.available | 2015-11-20T11:01:00Z | |
dc.date.available | 2016-06-02T11:52:29Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | PLoS ONE 2013, 8(6:e66288) | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2391214 | |
dc.description.abstract | Background: There is limited knowledge about atrial myocyte Ca2+ handling in the failing hearts. The aim of this study was to examine atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart failure (HF) and to examine whether aerobic interval training could reverse a potential dysfunction.
Methods and results: Post-infarction HF was induced in Sprague Dawley rats by ligation of the left descending coronary artery. Atrial myocyte shortening was depressed (p<0.01) and time to relaxation was prolonged (p<0.01) in sedentary HF-rats compared to healthy controls. This was associated with decreased Ca2+ amplitude, decreased SR Ca2+ content, and slower Ca2+ transient decay. Atrial myocytes from HF-rats had reduced sarcoplasmic reticulum Ca2+ ATPase activity, increased Na+/Ca2+-exchanger activity and increased diastolic Ca2+ leak through ryanodine receptors. High intensity aerobic interval training in HF-rats restored atrial myocyte contractile function and reversed changes in atrial Ca2+ handling in HF.
Conclusion: Post infarction HF in rats causes profound impairment in atrial myocyte contractile function and Ca2+ handling. The observed dysfunction in atrial myocytes was partly reversed after aerobic interval training. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.title | Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.date.updated | 2015-11-20T11:01:00Z | |
dc.source.volume | 8 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0066288 | |
dc.identifier.cristin | 1047167 | |
dc.description.localcode | © 2013 Johnsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |