dc.contributor.author | Lian, Ingrid Alsos | |
dc.contributor.author | Langaas, Mette | |
dc.contributor.author | Moses, Eric | |
dc.contributor.author | Johansson, Åsa | |
dc.date.accessioned | 2015-11-20T10:51:39Z | |
dc.date.accessioned | 2016-05-18T13:16:17Z | |
dc.date.available | 2015-11-20T10:51:39Z | |
dc.date.available | 2016-05-18T13:16:17Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | PLoS ONE 2013, 8(7) | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2389625 | |
dc.description.abstract | Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-placental tissue. By pooling data from three genome-wide transcription studies of the maternal-fetal interface, we have evaluated the relative effect of gestational age and PE on gene expression. A total of 18,180 transcripts were evaluated in 49 PE cases and 105 controls, with gestational age ranging from week 14 to 42. A total of 22 transcripts were associated with PE, whereas 92 transcripts with gestational age (nominal P value <1.51*10−6, Bonferroni adjusted P value <0.05). Our results indicate that gestational age has a great influence on gene expression both in normal and PE-complicated pregnancies. This effect might introduce serious bias in data analyses and needs to be carefully assessed in future genome-wide transcription studies. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.title | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.date.updated | 2015-11-20T10:51:39Z | |
dc.source.volume | 8 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 7 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0069848 | |
dc.identifier.cristin | 1058669 | |
dc.description.localcode | © 2013 Lian et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |