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dc.contributor.authorPintzka, Carl Wolfgang Schøyen
dc.contributor.authorHåberg, Asta
dc.date.accessioned2015-10-05T10:58:47Z
dc.date.accessioned2016-04-27T13:30:51Z
dc.date.available2015-10-05T10:58:47Z
dc.date.available2016-04-27T13:30:51Z
dc.date.issued2015
dc.identifier.citationNeurobiology of Aging 2015, 36(9):2555-2562nb_NO
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/11250/2387649
dc.description.abstractObservational studies support a neuroprotective role of hormone therapy (HT) in the perimenopause, with hippocampal size being a widely used biomarker.We investigated the effect of HT started before the onset of menopause and lasting for at least 3 years on hippocampal volume and shape in 80 postmenopausal women and 80 controls matched on age and intracranial volume taken from a large community-based sample (Nord-Trøndelag Health Studyemagnetic resonance imaging). The main effect of hormone group showed a statistically significant difference in hippocampal volumes (p ¼ 0.028). Both the right (3.2%) and left (2.8%) hippocampal volumes were larger in the HT group but only significant for the right hippocampus (p ¼ 0.023). Shape analysis revealed significant regional sparing of the medial aspect of the right hippocampal head and lateral aspect of the body extending to the tail, corresponding to the cornu ammonis, including part of the subiculum, in the HT group. A similar nonsignificant pattern was observed in the left hippocampus. The present study provides support for the critical window theory demonstrating that HT initiated in the perimenopause has neuroprotective properties.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.relation.urihttp://ac.els-cdn.com/S0197458015003073/1-s2.0-S0197458015003073-main.pdf?_tid=e2526906-6b4f-11e5-a919-00000aacb35e&acdnat=1444042834_ff5fbfbd51daa477cc44b47fbdd86195
dc.rightsNavngivelse 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/no/*
dc.titlePerimenopausal hormone therapy is associated with regional sparing of the CA1 subfield: a HUNT MRI studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2015-10-05T10:58:47Z
dc.source.volume36nb_NO
dc.source.journalNeurobiology of Agingnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1016/j.neurobiolaging.2015.05.023
dc.identifier.cristin1278410
dc.description.localcode2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).nb_NO


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