Show simple item record

dc.contributor.authorSølsnes, Anne Elisabeth
dc.contributor.authorSripada, Kam
dc.contributor.authorYendiki, Anastasia
dc.contributor.authorBjuland, Knut Jørgen
dc.contributor.authorØstgård, Heidi Furre
dc.contributor.authorAanes, Synne
dc.contributor.authorGrunewaldt, Kristine Hermansen
dc.contributor.authorLøhaugen, Gro
dc.contributor.authorEikenes, Live
dc.contributor.authorHåberg, Asta
dc.contributor.authorRimol, Lars Morten
dc.contributor.authorSkranes, Jon Sverre
dc.identifier.citationNeuroImage 2015, Dec 20nb_NO
dc.description.abstractPreterm birth and very low birth weight (VLBW, ≤ 1500 g) are worldwide problems that burden survivors with lifelong cognitive, psychological, and physical challenges. In this multimodal structural magnetic resonance imaging (MRI) and diffusion MRI (dMRI) study, we investigated differences in subcortical brain volumes and white matter tract properties in children born preterm with VLBW compared to term-born controls (mean age = 8 years). Subcortical brain structure volumes and cortical thickness estimates were obtained, and fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were generated for 18 white matter tracts. We also assessed structural relationships between white matter tracts and cortical thickness of the tract endpoints. Compared to controls, the VLBW group had reduced volumes of thalamus, globus pallidus, corpus callosum, cerebral white matter, ventral diencephalon, and brain stem, while the ventricular system was larger in VLBW subjects, after controlling for age, sex, IQ, and estimated total intracranial volume. For the dMRI parameters, group differences were not significant at the whole-tract level, though pointwise analysis found shorter segments affected in forceps minor and left superior longitudinal fasciculus – temporal bundle. IQ did not correlate with subcortical volumes or dMRI measures in the VLBW group. While the deviations in subcortical volumes were substantial, there were few differences in dMRI measures between the two groups, which may reflect the influence of advances in perinatal care on white matter development.nb_NO
dc.subjectDTI; Cohort study; Connectivity; Tractography; Premature; Developmentnb_NO
dc.titleLimited microstructural and connectivity deficits despite subcortical volume reductions in school-aged children born preterm with very low birth weight.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.localcodeCopyright © 2015 The Authors. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)nb_NO

Files in this item


This item appears in the following Collection(s)

Show simple item record
Except where otherwise noted, this item's license is described as