• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • Øvrige samlinger
  • Publikasjoner fra CRIStin - NTNU
  • View Item
  •   Home
  • Øvrige samlinger
  • Publikasjoner fra CRIStin - NTNU
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life

Jakola, Asgeir S; Unsgård, Geirmund; Myrmel, Kristin Smistad; Kloster, Roar; Torp, Sverre Helge; Lindal, Sigurd; Solheim, Ole
Journal article, Peer reviewed
Thumbnail
View/Open
fetchObject55506.pdf (378.3Kb)
URI
http://hdl.handle.net/11250/2365450
Date
2012
Metadata
Show full item record
Collections
  • Institutt for nevromedisin og bevegelsesvitenskap [2360]
  • Institutt for sirkulasjon og bildediagnostikk [1407]
  • Publikasjoner fra CRIStin - NTNU [26736]
Original version
PLoS ONE 2012, 7(12)   10.1371/journal.pone.0051450
Abstract
Background: Surgical management of suspected LGG remains controversial. A key factor when deciding a surgical strategy

is often the tumors’ perceived relationship to eloquent brain regions

Objective: To study the association between tumor location, survival and long-term health related quality of life (HRQL) in

patients with supratentorial low-grade gliomas (LGG).

Methods: Adults ($18 years) operated due to newly diagnosed LGG from 1998 through 2009 included from two Norwegian

university hospitals. After review of initial histopathology, 153 adults with supratentorial WHO grade II LGG were included in

the study. Tumors’ anatomical location and the relationship to eloquent regions were graded. Survival analysis was adjusted

for known prognostic factors and the initial surgical procedure (biopsy or resection). In long-term survivors, HRQL was

assessed with disease specific questionnaires (EORTC QLQ-C30 and BN20) as well as a generic questionnaire (EuroQol 5D).

Results: There was a significant association between eloquence and survival (log-rank, p,0.001). The estimated 5-year

survival was 77% in non-eloquent tumors, 71% in intermediate located tumors and 54% in eloquent tumors. In the adjusted

analysis the hazard ratio of increasing eloquence was 1.5 (95% CI 1.1–2.0, p = 0.022). There were no differences in HRQL

between patients with eloquent and non-eloquent tumors. The most frequent self-reported symptoms were related to

fatigue, cognition, and future uncertainty.

Conclusion: Eloquently located LGGs are associated with impaired survival compared to non-eloquently located LGG, but in

long-term survivors HRQL is similar. Although causal inference from observational data should be done with caution, the

findings illuminate the delicate balance in surgical decision making in LGGs, and add support to the probable survival

benefits of aggressive surgical strategies, perhaps also in eloquent locations.
Publisher
Public Library of Science
Journal
PLoS ONE

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit