Vis enkel innførsel

dc.contributor.authorMorris, Richard W.
dc.contributor.authorTaylor, Amy E.
dc.contributor.authorFluharty, Meg E.
dc.contributor.authorBjørngaard, Johan Håkon
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorGabrielsen, Maiken Elvestad
dc.contributor.authorCampbell, Archie
dc.contributor.authorMarioni, Riccardo
dc.contributor.authorKumari, Meena
dc.contributor.authorKorhonen, Tellervo
dc.contributor.authorMännistö, Satu
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorKaakinen, Marika
dc.contributor.authorCavadino, Alana
dc.contributor.authorPostmus, Iris
dc.contributor.authorHusemoen, Lise Lotte N.
dc.contributor.authorSkaaby, Tea
dc.contributor.authorAhluwalia, Tarun Veer Singh
dc.contributor.authorTreur, Jorien L.
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorDale, Caroline
dc.contributor.authorWannamethee, S. Goya
dc.contributor.authorLahti, Jari
dc.contributor.authorPalotie, Aarno
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorMcConnachie, Alex
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorWong, Andrew
dc.contributor.authorDalgård, Christine
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorBen-Shlomo, Yoav
dc.contributor.authorTyrrell, Jessica
dc.contributor.authorHorwood, John
dc.contributor.authorFergusson, David M.
dc.contributor.authorKennedy, Martin A.
dc.contributor.authorNohr, Ellen A.
dc.contributor.authorChristiansen, Lene
dc.contributor.authorKyvik, Kirsten Ohm
dc.contributor.authorKuh, Diana
dc.contributor.authorWatt, Graham
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorWhincup, Peter H.
dc.contributor.authorVink, Jacqueline M.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorSmith, George Davey
dc.contributor.authorLawlor, Debbie
dc.contributor.authorLinneberg, Allan
dc.contributor.authorFord, Ian
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorPower, Chris
dc.contributor.authorHyppönen, Elina
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorPreisig, Martin
dc.contributor.authorBorodulin, Katja
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKivimaki, Mika
dc.contributor.authorSmith, Blair H.
dc.contributor.authorHayward, Caroline
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorSørensen, Thorkild I.A.
dc.contributor.authorMunafo, Marcus R.
dc.contributor.authorSattar, Naveed
dc.date.accessioned2015-11-10T11:45:08Z
dc.date.accessioned2015-11-23T15:45:35Z
dc.date.available2015-11-10T11:45:08Z
dc.date.available2015-11-23T15:45:35Z
dc.date.issued2015
dc.identifier.citationBMJ Open 2015, 5(8)nb_NO
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11250/2365370
dc.description.abstractObjectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants: 148 731 current, former and never-smokers of European ancestry aged ≥16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by −0.40% (95% CI −0.57% to −0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being −0.31% (95% CI −0.42% to −0.19), −0.08% (−0.19% to 0.03%) and −0.74% (−0.96% to −0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (−0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (−0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.titleHeavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortiumnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-11-10T11:45:08Z
dc.source.volume5nb_NO
dc.source.journalBMJ Opennb_NO
dc.source.issue8nb_NO
dc.identifier.doi10.1136/bmjopen-2015-008808
dc.identifier.cristin1285556
dc.description.localcodeThis is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/nb_NO


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel