dc.contributor.author | Karlsen, Morten | |
dc.contributor.author | Liu, Huiling | |
dc.contributor.author | Johansen, Jon Eigill | |
dc.contributor.author | Hoff, Bård Helge | |
dc.date.accessioned | 2015-09-30T12:32:51Z | |
dc.date.accessioned | 2015-11-06T12:31:35Z | |
dc.date.available | 2015-09-30T12:32:51Z | |
dc.date.available | 2015-11-06T12:31:35Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Molecules 2015, 20(4):5329-5345 | nb_NO |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/11250/2359594 | |
dc.description.abstract | The illegal use of opiates and cocaine is a challenge world-wide, but some
derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients
and their metabolites are needed both for controlling administration in the clinic and to
detect drugs of abuse. Especially, 13C-labeled compounds are useful for identification and
quantification purposes by mass spectroscopic techniques, potentially increasing accuracy
by minimizing ion alteration/suppression effects. Thus, the synthesis of [acetyl-13C4]heroin,
[acetyl-13C4-methyl-13C]heroin, [acetyl-13C2-methyl-13C]6-acetylmorphine, [N-methyl-13C-Ometyl-
13C]codeine and phenyl-13C6-labeled derivatives of cocaine, benzoylecgonine,
norcocaine and cocaethylene was undertaken to provide such reference materials. The
synthetic work has focused on identifying 13C atom-efficient routes towards these
derivatives. Therefore, the 13C-labeled opiates and cocaine derivatives were made from the
corresponding natural products. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | MDPI | nb_NO |
dc.title | Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | en_GB |
dc.date.updated | 2015-09-30T12:32:51Z | |
dc.source.volume | 20 | nb_NO |
dc.source.journal | Molecules | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.3390/molecules20045329 | |
dc.identifier.cristin | 1248225 | |
dc.description.localcode | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |