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Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes

Burri, Reto; Bolivar, Paulina; Husby, Arild; Qvarnström, Anna; Uebbing, Severin; Ellegren, Hans; Smeds, Linnea; Kawakami, Takeshi
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/2357933
Date
2014
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  • Institutt for biologi [1708]
  • Publikasjoner fra CRIStin - NTNU [22010]
Original version
Nature Communications 2014, 5   10.1038/ncomms6448
Abstract
The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes

remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated

avian sex chromosomes remains to be identified. Here we use linkage analysis

together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological

model species, the collared flycatcher. The PAR contains 22 protein-coding genes and

is GC rich. The genetic length is 64cM in female meiosis, consistent with an obligate

crossing-over event. Recombination is concentrated to a hotspot region, with an extreme rate

of 4700cM/Mb in a 67-kb segment. We find no signatures of sexual antagonism and

propose that sexual antagonism may have limited influence on PAR sequences when sex

chromosomes are nearly fully differentiated and when a recombination hotspot region is

located close to the PAR boundary. Our results demonstrate that a very small PAR suffices to

ensure homologous recombination and proper segregation of sex chromosomes during

meiosis.
Publisher
Nature Publishing Group
Journal
Nature Communications

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