| dc.description.abstract | Background: MR spectroscopy of intact biopsies can provide a metabolic snapshot of the investigated tissue. The
aim of the present study was to explore the metabolic pattern of uninvolved skin, psoriatic skin and corticosteroid
treated psoriatic skin.
Methods: The three types of skin biopsy samples were excised from patients with psoriasis (N = 10). Lesions were
evaluated clinically, and tissue biopsies were excised and analyzed by one-dimensional 1H MR spectroscopy.
Relative levels were calculated for nine tissue metabolites. Subsequently, relative amounts of epidermis, dermis and
subcutaneous tissue were scored by histopathological evaluation of HES stained sections.
Results: Seven out of 10 patients experienced at least 40% reduction in clinical score after corticosteroid treatment.
Tissue biopsies from psoriatic skin contained lower levels of the metabolites myo-inositol and glucose, and higher
levels of choline and taurine compared to uninvolved skin. In corticosteroid treated psoriatic skin, tissue levels of
glucose, myo-inositol, GPC and glycine were increased, whereas choline was reduced, in patients with good
therapeutic effect. These tissue levels are becoming more similar to metabolite levels in uninvolved skin.
Conclusion: This MR method demonstrates that metabolism in psoriatic skin becomes similar to that of uninvolved
skin after effective corticosteroid treatment. MR profiling of skin lesions reflect metabolic alterations related to
pathogenesis and treatment effects. | nb_NO |
