Angiotensin-converting enzyme gene insertion/deletion polymorphism in migraine patients
Tronvik, Erling; Stovner, Lars Jacob; Bovim, Gunnar; White, Linda; Gladwind, AJ; Owen, k; Schrader, Harald
Journal article, Peer reviewed
Permanent lenke
http://hdl.handle.net/11250/2353224Utgivelsesdato
2008Metadata
Vis full innførselSamlinger
Sammendrag
Background: The main objective of this study was to investigate the angiotensin converting
enzyme (ACE) genotype as a possible risk factor for migraine (both with and without aura)
compared to controls. We also wanted to examine whether a clinical response to an ACE inhibitor,
lisinopril, or an angiotensin II receptor blocker, candesartan, in migraine prophylaxis was related to
ACE genotype.
Methods: 347 migraine patients aged 18–68 (155 migraine without aura (MoA), 187 migraine with
aura (MwA) and 5 missing aura subgroup data) and 403 healthy non-migrainous controls > 40 years
of age were included in the study. A polymerase chain reaction (PCR) was performed on the
genomic DNA samples to obtain the ACE insertion (I)/deletion(D) polymorphisms.
Results: No significant differences between migraine patients and controls were found with regard
to ACE genotype and allele distributions. Furthermore, there was no significant difference between
the controls and the MwA or MoA subgroups.
Conclusion: In our sample there is no association between ACE genotype or allele frequency and
migraine. In addition, ACE genotype in our experience did not predict the clinical response to
lisinopril or candesartan used as migraine prophylactics.