Kavliinstitutt for nevrovitenskap: Nye registreringer
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Memory in the lab versus memory in the wild: How effectively do mechanisms generalize across contexts?
(Doctoral theses at NTNU;2024:162, Doctoral thesis, 2024)English summary A large portion of human interactions with the environment depends on the accurate estimation of spatial and temporal magnitudes in the order of seconds to minutes. Through these dynamic interactions, ... -
Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin
(Journal article; Peer reviewed, 2024)GABAergic neurons represent 10–15% of the neuronal population of the cortex but exert a powerful control over information flow in cortical circuits. The largest GABAergic class in the neocortex is represented by the ... -
Functional properties of entorhinal-hippocampal circuits - A spacetime odyssey
(Doctoral theses at NTNU;2024:123, Doctoral thesis, 2024) -
Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease
(Journal article; Peer reviewed, 2023) -
Adaptive spike threshold dynamics associated with sparse spiking of hilar mossy cells are captured by a simple model
(Peer reviewed; Journal article, 2023)Hilar mossy cells (hMCs) in the dentate gyrus (DG) receive inputs from DG granule cells (GCs), CA3 pyramidal cells and inhibitory interneurons, and provide feedback input to GCs. Behavioural and in vivo recording experiments ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
(Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Connecting the Dots: Integrating Visual Projections, Observational Learning, and Behavior Representation in Rodent Prefrontal Cortices
(Doctoral theses at NTNU;2024:17, Doctoral thesis, 2024)The medial prefrontal cortex (mPFC) has been studied extensively across species, across functions and across experimental paradigms. Despite this, we still have not fully elucidated what this brain area truly does and how, ... -
Multisensory input modulates memory-guided spatial navigation in humans
(Peer reviewed; Journal article, 2023)Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation ... -
Mental search of concepts is supported by egocentric vector representations and restructured grid maps
(Peer reviewed; Journal article, 2023)The human hippocampal-entorhinal system is known to represent both spatial locations and abstract concepts in memory in the form of allocentric cognitive maps. Using fMRI, we show that the human parietal cortex evokes ... -
Klotho and GPLD-1: Predictive Biomarkers for Development of Alzheimer's Disease in Older Adults
(Master thesis, 2023)Bakgrunn: Alzheimers sykdom (AD) er en nevrodegenerativ sykdom og den vanligste formen for demens. I 2023 påvirker demens over 55 millioner mennesker globalt, og det er forventet å øke til 152 millioner innen 2050. Likevel ... -
Organization of projections from the entorhinal cortex to the hippocampal formation of the Egyptian fruit bat Rousettus aegyptiacus
(Peer reviewed; Journal article, 2023)The hippocampal formation and entorhinal cortex are crucially involved in learning and memory as well as in spatial navigation. The conservation of these structures across the entire mammalian lineage demonstrates their ... -
Architectural organization of ∼1,500-neuron modular minicolumnar disinhibitory circuits in healthy and Alzheimer's cortices
(Peer reviewed; Journal article, 2023)Acquisition of neuronal circuit architectures, central to understanding brain function and dysfunction, remains prohibitively challenging. Here I report the development of a simultaneous and sequential octuple-sexdecuple ... -
Projections of the insular cortex to orbitofrontal and medial prefrontal cortex: A tracing study in the rat
(Peer reviewed; Journal article, 2023)The dense fiber pathways that connect the insular cortex with frontal cortices are thought to provide these frontal areas with interoceptive information, crucial for their involvement in executive functions. Using anterograde ... -
Behavioral decomposition reveals rich encoding structure employed across neocortex in rats
(Peer reviewed; Journal article, 2023)The cortical population code is pervaded by activity patterns evoked by movement, but it remains largely unknown how such signals relate to natural behavior or how they might support processing in sensory cortices where ... -
Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways
(Peer reviewed; Journal article, 2023)Introduction: The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. ... -
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
(Peer reviewed; Journal article, 2023)Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal Alzheimer’s disease. A ... -
Landmark-based spatial navigation across the human lifespan
(Journal article; Peer reviewed, 2023) -
Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease
(Journal article; Peer reviewed, 2023) -
Defensive Behaviors in Juvenile Zebrafish, and the Impact of Serotonergic Manipulation on Their Behavioral Phenotype
(Master thesis, 2023)Det overordnede målet med denne avhandlingen er å utforske forsvarsadferd hos juvenile sebrafisker, med særlig interesse for hvordan manipulering av det serotonergiske systemet påvirker uttrykket av disse adferdsresponsene. ... -
Integration and Segregation of Emotion Regulation Networks in Aging A Graph Theoretical Analysis on Resting State fMRI from the Human Connectome Project - Aging
(Master thesis, 2023)Growing old is often accompanied by a number of physical and behavioral changes. This includes, how emotions are perceived and regulated, which changes across the lifespan. In fact, with increasing age we observe improved ...