Blar i Kavliinstitutt for nevrovitenskap på forfatter "Aydin, Ecem"
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Glia-neuron interactions underlie state transitions to generalized seizures
Diaz Verdugo, Carmen; Myren-Svelstad, Sverre; Aydin, Ecem; Van Hoeymissen, Evelien; Deneubourg, Celine; Vanderhaeghe, Silke; Vancraeynest, Julie; Pelgrims, Robbrecht; Casacak, Mehmet Ilyas; Muto, Akira; Kawakami, Koichi; Jurisch-Yaksi, Nathalie; Yaksi, Emre (Journal article; Peer reviewed, 2019)Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms ... -
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...