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The role of hippocampal spatial representations in contextualization and generalization of fear
(Journal article; Peer reviewed, 2019)Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations ... -
The role of mental maps in decision-making
(Journal article; Peer reviewed, 2017)A growing body of work is investigating the use of mental maps during decision-making. Here we discuss how decision-making organizes experiences according to an internal model of the current task, thereby structuring memory. ... -
The spatial representations acquired in CA3 by self-organizing recurrent connections
(Journal article; Peer reviewed, 2013)Neural computation models have hypothesized that the dentate gyrus (DG) drives the storage in the CA3 network of new memories including, e.g., in rodents, spatial memories. Can recurrent CA3 connections self-organize, ... -
The Stochastic Complexity of Spin Models: Are Pairwise Models Really Simple?
(Journal article; Peer reviewed, 2018)Models can be simple for different reasons: because they yield a simple and computationally efficient interpretation of a generic dataset (e.g., in terms of pairwise dependencies)—as in statistical learning—or because they ... -
The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action
(Journal article; Peer reviewed, 2018)How do we decide what we do? This is the essence of action control, the process of selecting the most appropriate response among multiple possible choices. Suboptimal action control can involve a failure to initiate or ... -
The Time Window for Generation of Dendritic Spikes by Coincidence of Action Potentials and EPSPs is Layer Specific in Somatosensory Cortex
(Journal article; Peer reviewed, 2012)The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have ... -
Theta phase-coordinated memory reactivation reoccurs in a slow-oscillatory rhythm during NREM sleep
(Journal article; Peer reviewed, 2018)It has been proposed that sleep’s contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated ... -
Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus
(Journal article; Peer reviewed, 2015)We asked whether the structural heterogeneity of the hippocampal CA3-CA2 axis is reflected in how space is mapped onto place cells in CA3-CA2. Place fields were smaller and sharper in proximal CA3 than in distal CA3 and ... -
Toroidal topology of population activity in grid cells
(Journal article; Peer reviewed, 2022)The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment1. Grid cells, a key component of this system, fire in a characteristic hexagonal pattern of ... -
Towards modeling of neuronal networks in HUWE1-induced XLID
(Master thesis, 2020)Intellektuell forstyrrelse (ID) er en utviklingsforstyrrelse karakterisert av manglende intellektuelle funksjoner og adaptive evner. Denne lidelsen rammer tilnærmet 2% av den vestlige populasjonen. X-koblet ID (XLID) er ... -
Trans-Synaptic Spread of Tau Pathology In Vivo
(Journal article; Peer reviewed, 2012)Tauopathy in the brain of patients with Alzheimer’s disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether pathology initiating in the EC spreads through the brain along ... -
TU-tagging: A method for identifying layer-enriched neuronal genes in developing mouse visual cortex
(Journal article; Peer reviewed, 2017)Thiouracil (TU)-tagging is an intersectional method for covalently labeling newly transcribed RNAs within specific cell types. Cell type specificity is generated through targeted transgenic expression of the enzyme uracil ... -
Updating of visual orientation in a gravity-based reference frame
(Journal article; Peer reviewed, 2017)The brain can use multiple reference frames to code line orientation, including head-, object-, and gravity-centered references. If these frames change orientation, their representations must be updated to keep register ... -
Using microdialysis to administer and assess drugs aimed at attenuating Alzheimer’s disease-related neuropathology
(Master thesis, 2021)Alzheimer’s disease is the most common form of dementia and is characterized by the neuropathological hallmarks amyloid-β and neurofibrillary tangles. Despite tremendous efforts in understanding the molecular, pathophysiological, ... -
Using persistent homology to reveal hidden covariates in systems governed by the kinetic Ising model
(Journal article; Peer reviewed, 2018)We propose a method, based on persistent homology, to uncover topological properties of a priori unknown covariates in a system governed by the kinetic Ising model with time-varying external fields. As its starting point ... -
Value of information of in-situ inspections of mooring lines
(Peer reviewed; Journal article, 2021)Mooring systems that are used to secure position keeping of floating offshore oil and gas facilities are subject to deterioration processes, such as pitting corrosion and fatigue crack growth. Past investigations show that ... -
Visual and tactile representation of social interactions in mouse secondary motor and anterior cingulate cortices
(Master thesis, 2019)Secondary motor (M2) and anterior cingulate (ACC) cortices are frontal association areas in the rodent brain that receive substantial information from several primary and associative areas, including visual and posterior ... -
Visual stimulus features that elicit activity in object-vector cells
(Peer reviewed; Journal article, 2021)Object-vector (OV) cells are cells in the medial entorhinal cortex (MEC) that track an animal’s distance and direction to objects in the environment. Their firing fields are defined by vectorial relationships to free-standing ... -
Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways
(Peer reviewed; Journal article, 2023)Introduction: The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. ... -
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
(Peer reviewed; Journal article, 2021)The NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations ...